diff --git a/pandas/compat/pickle_compat.py b/pandas/compat/pickle_compat.py
index ef9f36705a7ee..80ee1f2e20154 100644
--- a/pandas/compat/pickle_compat.py
+++ b/pandas/compat/pickle_compat.py
@@ -274,7 +274,7 @@ def patch_pickle():
     """
     orig_loads = pkl.loads
     try:
-        pkl.loads = loads
+        setattr(pkl, "loads", loads)
         yield
     finally:
-        pkl.loads = orig_loads
+        setattr(pkl, "loads", orig_loads)
diff --git a/setup.cfg b/setup.cfg
index 3279a485c9bf3..93564bc3908d6 100644
--- a/setup.cfg
+++ b/setup.cfg
@@ -136,9 +136,6 @@ check_untyped_defs=False
 [mypy-pandas._version]
 check_untyped_defs=False
 
-[mypy-pandas.compat.pickle_compat]
-check_untyped_defs=False
-
 [mypy-pandas.core.apply]
 check_untyped_defs=False