diff --git a/.pre-commit-config.yaml b/.pre-commit-config.yaml
index 7f669ee77c3eb..d0c9f12614d0d 100644
--- a/.pre-commit-config.yaml
+++ b/.pre-commit-config.yaml
@@ -43,3 +43,7 @@ repos:
         entry: python -m scripts.generate_pip_deps_from_conda
         files: ^(environment.yml|requirements-dev.txt)$
         pass_filenames: false
+-   repo: https://github.com/asottile/yesqa
+    rev: v1.2.2
+    hooks:
+    -   id: yesqa
diff --git a/asv_bench/benchmarks/pandas_vb_common.py b/asv_bench/benchmarks/pandas_vb_common.py
index 23286343d7367..7bd4d639633b3 100644
--- a/asv_bench/benchmarks/pandas_vb_common.py
+++ b/asv_bench/benchmarks/pandas_vb_common.py
@@ -15,7 +15,7 @@
 
 # Compatibility import for the testing module
 try:
-    import pandas._testing as tm  # noqa
+    import pandas._testing as tm
 except ImportError:
     import pandas.util.testing as tm  # noqa
 
diff --git a/asv_bench/benchmarks/tslibs/offsets.py b/asv_bench/benchmarks/tslibs/offsets.py
index fc1efe63307b2..0aea8332398b1 100644
--- a/asv_bench/benchmarks/tslibs/offsets.py
+++ b/asv_bench/benchmarks/tslibs/offsets.py
@@ -9,7 +9,7 @@
 from pandas import offsets
 
 try:
-    import pandas.tseries.holiday  # noqa
+    import pandas.tseries.holiday
 except ImportError:
     pass
 
diff --git a/doc/source/conf.py b/doc/source/conf.py
index 04540f7e6ec95..15e7a13ff5b72 100644
--- a/doc/source/conf.py
+++ b/doc/source/conf.py
@@ -146,7 +146,7 @@
 # built documents.
 #
 # The short X.Y version.
-import pandas  # noqa: E402 isort:skip
+import pandas  # isort:skip
 
 # version = '%s r%s' % (pandas.__version__, svn_version())
 version = str(pandas.__version__)
@@ -441,14 +441,14 @@
 # Add custom Documenter to handle attributes/methods of an AccessorProperty
 # eg pandas.Series.str and pandas.Series.dt (see GH9322)
 
-import sphinx  # noqa: E402 isort:skip
-from sphinx.util import rpartition  # noqa: E402 isort:skip
-from sphinx.ext.autodoc import (  # noqa: E402 isort:skip
+import sphinx  # isort:skip
+from sphinx.util import rpartition  # isort:skip
+from sphinx.ext.autodoc import (  # isort:skip
     AttributeDocumenter,
     Documenter,
     MethodDocumenter,
 )
-from sphinx.ext.autosummary import Autosummary  # noqa: E402 isort:skip
+from sphinx.ext.autosummary import Autosummary  # isort:skip
 
 
 class AccessorDocumenter(MethodDocumenter):
diff --git a/pandas/_typing.py b/pandas/_typing.py
index 16d81c0d39cbe..7678d1bf12d8b 100644
--- a/pandas/_typing.py
+++ b/pandas/_typing.py
@@ -27,16 +27,16 @@
 # and use a string literal forward reference to it in subsequent types
 # https://mypy.readthedocs.io/en/latest/common_issues.html#import-cycles
 if TYPE_CHECKING:
-    from pandas._libs import Period, Timedelta, Timestamp  # noqa: F401
+    from pandas._libs import Period, Timedelta, Timestamp
 
-    from pandas.core.dtypes.dtypes import ExtensionDtype  # noqa: F401
+    from pandas.core.dtypes.dtypes import ExtensionDtype
 
-    from pandas import Interval  # noqa: F401
+    from pandas import Interval
     from pandas.core.arrays.base import ExtensionArray  # noqa: F401
-    from pandas.core.frame import DataFrame  # noqa: F401
+    from pandas.core.frame import DataFrame
     from pandas.core.generic import NDFrame  # noqa: F401
-    from pandas.core.indexes.base import Index  # noqa: F401
-    from pandas.core.series import Series  # noqa: F401
+    from pandas.core.indexes.base import Index
+    from pandas.core.series import Series
 
 # array-like
 
diff --git a/pandas/api/types/__init__.py b/pandas/api/types/__init__.py
index 3495b493707c2..fb1abdd5b18ec 100644
--- a/pandas/api/types/__init__.py
+++ b/pandas/api/types/__init__.py
@@ -4,7 +4,7 @@
 
 from pandas._libs.lib import infer_dtype
 
-from pandas.core.dtypes.api import *  # noqa: F403, F401
+from pandas.core.dtypes.api import *  # noqa: F401, F403
 from pandas.core.dtypes.concat import union_categoricals
 from pandas.core.dtypes.dtypes import (
     CategoricalDtype,
diff --git a/pandas/conftest.py b/pandas/conftest.py
index 3865d287c6905..5ac5e3670f69f 100644
--- a/pandas/conftest.py
+++ b/pandas/conftest.py
@@ -1226,7 +1226,7 @@ def ip():
     from IPython.core.interactiveshell import InteractiveShell
 
     # GH#35711 make sure sqlite history file handle is not leaked
-    from traitlets.config import Config  # noqa: F401 isort:skip
+    from traitlets.config import Config  # isort:skip
 
     c = Config()
     c.HistoryManager.hist_file = ":memory:"
diff --git a/pandas/core/arrays/floating.py b/pandas/core/arrays/floating.py
index c3710196a8611..33659fe2f397d 100644
--- a/pandas/core/arrays/floating.py
+++ b/pandas/core/arrays/floating.py
@@ -34,7 +34,7 @@
 from .masked import BaseMaskedArray, BaseMaskedDtype
 
 if TYPE_CHECKING:
-    import pyarrow  # noqa: F401
+    import pyarrow
 
 
 class FloatingDtype(BaseMaskedDtype):
@@ -82,7 +82,7 @@ def __from_arrow__(
         """
         Construct FloatingArray from pyarrow Array/ChunkedArray.
         """
-        import pyarrow  # noqa: F811
+        import pyarrow
 
         from pandas.core.arrays._arrow_utils import pyarrow_array_to_numpy_and_mask
 
diff --git a/pandas/io/common.py b/pandas/io/common.py
index f177e08ac0089..c147ae9fd0aa8 100644
--- a/pandas/io/common.py
+++ b/pandas/io/common.py
@@ -53,7 +53,7 @@
 
 
 if TYPE_CHECKING:
-    from io import IOBase  # noqa: F401
+    from io import IOBase
 
 
 def is_url(url) -> bool:
diff --git a/pandas/io/formats/console.py b/pandas/io/formats/console.py
index bed29e1fd4792..50e69f7e8b435 100644
--- a/pandas/io/formats/console.py
+++ b/pandas/io/formats/console.py
@@ -69,7 +69,7 @@ def check_main():
         return not hasattr(main, "__file__") or get_option("mode.sim_interactive")
 
     try:
-        return __IPYTHON__ or check_main()  # noqa
+        return __IPYTHON__ or check_main()
     except NameError:
         return check_main()
 
@@ -83,7 +83,7 @@ def in_ipython_frontend():
     bool
     """
     try:
-        ip = get_ipython()  # noqa
+        ip = get_ipython()
         return "zmq" in str(type(ip)).lower()
     except NameError:
         pass
diff --git a/pandas/io/formats/info.py b/pandas/io/formats/info.py
index e8e41d4325103..5c6ce23707781 100644
--- a/pandas/io/formats/info.py
+++ b/pandas/io/formats/info.py
@@ -12,7 +12,7 @@
 from pandas.io.formats.printing import pprint_thing
 
 if TYPE_CHECKING:
-    from pandas.core.series import Series  # noqa: F401
+    from pandas.core.series import Series
 
 
 def _put_str(s: Union[str, Dtype], space: int) -> str:
diff --git a/pandas/io/json/_table_schema.py b/pandas/io/json/_table_schema.py
index 84146a5d732e1..2b4c86b3c4406 100644
--- a/pandas/io/json/_table_schema.py
+++ b/pandas/io/json/_table_schema.py
@@ -26,7 +26,7 @@
 import pandas.core.common as com
 
 if TYPE_CHECKING:
-    from pandas.core.indexes.multi import MultiIndex  # noqa: F401
+    from pandas.core.indexes.multi import MultiIndex
 
 loads = json.loads
 
diff --git a/pandas/io/pytables.py b/pandas/io/pytables.py
index d62480baed71e..ef9a4526a3fab 100644
--- a/pandas/io/pytables.py
+++ b/pandas/io/pytables.py
@@ -57,7 +57,7 @@
 from pandas.io.formats.printing import adjoin, pprint_thing
 
 if TYPE_CHECKING:
-    from tables import Col, File, Node  # noqa:F401
+    from tables import Col, File, Node
 
 
 # versioning attribute
diff --git a/pandas/io/sas/sasreader.py b/pandas/io/sas/sasreader.py
index 893a6286f74d4..caf53b5be971a 100644
--- a/pandas/io/sas/sasreader.py
+++ b/pandas/io/sas/sasreader.py
@@ -9,7 +9,7 @@
 from pandas.io.common import get_filepath_or_buffer, stringify_path
 
 if TYPE_CHECKING:
-    from pandas import DataFrame  # noqa: F401
+    from pandas import DataFrame
 
 
 # TODO(PY38): replace with Protocol in Python 3.8
diff --git a/pandas/plotting/_matplotlib/__init__.py b/pandas/plotting/_matplotlib/__init__.py
index 27b1d55fe1bd6..33011e6a66cac 100644
--- a/pandas/plotting/_matplotlib/__init__.py
+++ b/pandas/plotting/_matplotlib/__init__.py
@@ -29,7 +29,7 @@
 from pandas.plotting._matplotlib.tools import table
 
 if TYPE_CHECKING:
-    from pandas.plotting._matplotlib.core import MPLPlot  # noqa: F401
+    from pandas.plotting._matplotlib.core import MPLPlot
 
 PLOT_CLASSES: Dict[str, Type["MPLPlot"]] = {
     "line": LinePlot,
diff --git a/pandas/plotting/_matplotlib/timeseries.py b/pandas/plotting/_matplotlib/timeseries.py
index f8faac6a6a026..64cd43c230f28 100644
--- a/pandas/plotting/_matplotlib/timeseries.py
+++ b/pandas/plotting/_matplotlib/timeseries.py
@@ -26,7 +26,7 @@
 if TYPE_CHECKING:
     from matplotlib.axes import Axes
 
-    from pandas import Index, Series  # noqa:F401
+    from pandas import Index, Series
 
 # ---------------------------------------------------------------------
 # Plotting functions and monkey patches
diff --git a/pandas/plotting/_matplotlib/tools.py b/pandas/plotting/_matplotlib/tools.py
index aed0c360fc7ce..832957dd73ec7 100644
--- a/pandas/plotting/_matplotlib/tools.py
+++ b/pandas/plotting/_matplotlib/tools.py
@@ -17,7 +17,7 @@
 if TYPE_CHECKING:
     from matplotlib.axes import Axes
     from matplotlib.axis import Axis
-    from matplotlib.lines import Line2D  # noqa:F401
+    from matplotlib.lines import Line2D
     from matplotlib.table import Table
 
 
diff --git a/pandas/tests/arrays/categorical/test_constructors.py b/pandas/tests/arrays/categorical/test_constructors.py
index e200f13652a84..1eef86980f974 100644
--- a/pandas/tests/arrays/categorical/test_constructors.py
+++ b/pandas/tests/arrays/categorical/test_constructors.py
@@ -213,7 +213,7 @@ def test_constructor(self):
         #  - when the first is an integer dtype and the second is not
         #  - when the resulting codes are all -1/NaN
         with tm.assert_produces_warning(None):
-            c_old = Categorical([0, 1, 2, 0, 1, 2], categories=["a", "b", "c"])  # noqa
+            c_old = Categorical([0, 1, 2, 0, 1, 2], categories=["a", "b", "c"])
 
         with tm.assert_produces_warning(None):
             c_old = Categorical([0, 1, 2, 0, 1, 2], categories=[3, 4, 5])  # noqa
diff --git a/pandas/tests/arrays/categorical/test_repr.py b/pandas/tests/arrays/categorical/test_repr.py
index 735b062eae80e..e23fbb16190ea 100644
--- a/pandas/tests/arrays/categorical/test_repr.py
+++ b/pandas/tests/arrays/categorical/test_repr.py
@@ -320,7 +320,7 @@ def test_categorical_repr_timedelta(self):
 
         c = Categorical(idx.append(idx), categories=idx)
         exp = """[1 days, 2 days, 3 days, 4 days, 5 days, 1 days, 2 days, 3 days, 4 days, 5 days]
-Categories (5, timedelta64[ns]): [1 days, 2 days, 3 days, 4 days, 5 days]"""  # noqa
+Categories (5, timedelta64[ns]): [1 days, 2 days, 3 days, 4 days, 5 days]"""
 
         assert repr(c) == exp
 
@@ -347,13 +347,13 @@ def test_categorical_repr_timedelta_ordered(self):
         idx = timedelta_range("1 days", periods=5)
         c = Categorical(idx, ordered=True)
         exp = """[1 days, 2 days, 3 days, 4 days, 5 days]
-Categories (5, timedelta64[ns]): [1 days < 2 days < 3 days < 4 days < 5 days]"""  # noqa
+Categories (5, timedelta64[ns]): [1 days < 2 days < 3 days < 4 days < 5 days]"""
 
         assert repr(c) == exp
 
         c = Categorical(idx.append(idx), categories=idx, ordered=True)
         exp = """[1 days, 2 days, 3 days, 4 days, 5 days, 1 days, 2 days, 3 days, 4 days, 5 days]
-Categories (5, timedelta64[ns]): [1 days < 2 days < 3 days < 4 days < 5 days]"""  # noqa
+Categories (5, timedelta64[ns]): [1 days < 2 days < 3 days < 4 days < 5 days]"""
 
         assert repr(c) == exp
 
diff --git a/pandas/tests/arrays/sparse/test_libsparse.py b/pandas/tests/arrays/sparse/test_libsparse.py
index 2d6e657debdb2..517dc4a2c3d8b 100644
--- a/pandas/tests/arrays/sparse/test_libsparse.py
+++ b/pandas/tests/arrays/sparse/test_libsparse.py
@@ -452,7 +452,7 @@ def test_check_integrity(self):
 
         # 0-length OK
         # TODO: index variables are not used...is that right?
-        index = BlockIndex(0, locs, lengths)  # noqa
+        index = BlockIndex(0, locs, lengths)
 
         # also OK even though empty
         index = BlockIndex(1, locs, lengths)  # noqa
diff --git a/pandas/tests/computation/test_eval.py b/pandas/tests/computation/test_eval.py
index cca64a6bf487c..bce1695b56a99 100644
--- a/pandas/tests/computation/test_eval.py
+++ b/pandas/tests/computation/test_eval.py
@@ -48,7 +48,7 @@
         )
         for engine in ENGINES
     )
-)  # noqa
+)
 def engine(request):
     return request.param
 
@@ -1885,7 +1885,7 @@ def test_global_scope(self, engine, parser):
         )
 
     def test_no_new_locals(self, engine, parser):
-        x = 1  # noqa
+        x = 1
         lcls = locals().copy()
         pd.eval("x + 1", local_dict=lcls, engine=engine, parser=parser)
         lcls2 = locals().copy()
@@ -1995,8 +1995,8 @@ def test_bool_ops_fails_on_scalars(lhs, cmp, rhs, engine, parser):
     gen = {int: lambda: np.random.randint(10), float: np.random.randn}
 
     mid = gen[lhs]()  # noqa
-    lhs = gen[lhs]()  # noqa
-    rhs = gen[rhs]()  # noqa
+    lhs = gen[lhs]()
+    rhs = gen[rhs]()
 
     ex1 = f"lhs {cmp} mid {cmp} rhs"
     ex2 = f"lhs {cmp} mid and mid {cmp} rhs"
diff --git a/pandas/tests/dtypes/test_inference.py b/pandas/tests/dtypes/test_inference.py
index e40a12f7bc8d1..c6c54ccb357d5 100644
--- a/pandas/tests/dtypes/test_inference.py
+++ b/pandas/tests/dtypes/test_inference.py
@@ -1495,7 +1495,7 @@ def test_nan_to_nat_conversions():
 
 @td.skip_if_no_scipy
 @pytest.mark.filterwarnings("ignore::PendingDeprecationWarning")
-def test_is_scipy_sparse(spmatrix):  # noqa: F811
+def test_is_scipy_sparse(spmatrix):
     assert is_scipy_sparse(spmatrix([[0, 1]]))
     assert not is_scipy_sparse(np.array([1]))
 
diff --git a/pandas/tests/frame/indexing/test_indexing.py b/pandas/tests/frame/indexing/test_indexing.py
index b947be705a329..507d01f5b900c 100644
--- a/pandas/tests/frame/indexing/test_indexing.py
+++ b/pandas/tests/frame/indexing/test_indexing.py
@@ -1091,7 +1091,7 @@ def test_getitem_setitem_float_labels(self):
             cp.iloc[1.0:5] = 0
 
         with pytest.raises(TypeError, match=msg):
-            result = cp.iloc[1.0:5] == 0  # noqa
+            result = cp.iloc[1.0:5] == 0
 
         assert result.values.all()
         assert (cp.iloc[0:1] == df.iloc[0:1]).values.all()
diff --git a/pandas/tests/frame/test_block_internals.py b/pandas/tests/frame/test_block_internals.py
index 4a85da72bc8b1..1e404c572dd51 100644
--- a/pandas/tests/frame/test_block_internals.py
+++ b/pandas/tests/frame/test_block_internals.py
@@ -78,7 +78,7 @@ def test_consolidate_inplace(self, float_frame):
     def test_values_consolidate(self, float_frame):
         float_frame["E"] = 7.0
         assert not float_frame._mgr.is_consolidated()
-        _ = float_frame.values  # noqa
+        _ = float_frame.values
         assert float_frame._mgr.is_consolidated()
 
     def test_modify_values(self, float_frame):
diff --git a/pandas/tests/frame/test_query_eval.py b/pandas/tests/frame/test_query_eval.py
index 2994482fa5139..024403189409c 100644
--- a/pandas/tests/frame/test_query_eval.py
+++ b/pandas/tests/frame/test_query_eval.py
@@ -633,9 +633,7 @@ def test_chained_cmp_and_in(self):
         res = df.query(
             "a < b < c and a not in b not in c", engine=engine, parser=parser
         )
-        ind = (
-            (df.a < df.b) & (df.b < df.c) & ~df.b.isin(df.a) & ~df.c.isin(df.b)
-        )  # noqa
+        ind = (df.a < df.b) & (df.b < df.c) & ~df.b.isin(df.a) & ~df.c.isin(df.b)
         expec = df[ind]
         tm.assert_frame_equal(res, expec)
 
diff --git a/pandas/tests/indexes/categorical/test_formats.py b/pandas/tests/indexes/categorical/test_formats.py
index a5607224f6448..45089fd876ffc 100644
--- a/pandas/tests/indexes/categorical/test_formats.py
+++ b/pandas/tests/indexes/categorical/test_formats.py
@@ -18,7 +18,7 @@ def test_string_categorical_index_repr(self):
         expected = """CategoricalIndex(['a', 'bb', 'ccc', 'a', 'bb', 'ccc', 'a', 'bb', 'ccc', 'a',
                   'bb', 'ccc', 'a', 'bb', 'ccc', 'a', 'bb', 'ccc', 'a', 'bb',
                   'ccc', 'a', 'bb', 'ccc', 'a', 'bb', 'ccc', 'a', 'bb', 'ccc'],
-                 categories=['a', 'bb', 'ccc'], ordered=False, dtype='category')"""  # noqa
+                 categories=['a', 'bb', 'ccc'], ordered=False, dtype='category')"""
 
         assert repr(idx) == expected
 
@@ -49,7 +49,7 @@ def test_string_categorical_index_repr(self):
         expected = """CategoricalIndex(['あ', 'いい', 'ううう', 'あ', 'いい', 'ううう', 'あ', 'いい', 'ううう', 'あ',
                   'いい', 'ううう', 'あ', 'いい', 'ううう', 'あ', 'いい', 'ううう', 'あ', 'いい',
                   'ううう', 'あ', 'いい', 'ううう', 'あ', 'いい', 'ううう', 'あ', 'いい', 'ううう'],
-                 categories=['あ', 'いい', 'ううう'], ordered=False, dtype='category')"""  # noqa
+                 categories=['あ', 'いい', 'ううう'], ordered=False, dtype='category')"""
 
         assert repr(idx) == expected
 
@@ -84,7 +84,7 @@ def test_string_categorical_index_repr(self):
                   'ううう', 'あ', 'いい', 'ううう', 'あ', 'いい', 'ううう',
                   'あ', 'いい', 'ううう', 'あ', 'いい', 'ううう', 'あ', 'いい',
                   'ううう', 'あ', 'いい', 'ううう', 'あ', 'いい', 'ううう'],
-                 categories=['あ', 'いい', 'ううう'], ordered=False, dtype='category')"""  # noqa
+                 categories=['あ', 'いい', 'ううう'], ordered=False, dtype='category')"""
 
             assert repr(idx) == expected
 
diff --git a/pandas/tests/indexes/multi/test_formats.py b/pandas/tests/indexes/multi/test_formats.py
index 792dcf4c535e3..c1de7f79c2d2e 100644
--- a/pandas/tests/indexes/multi/test_formats.py
+++ b/pandas/tests/indexes/multi/test_formats.py
@@ -206,5 +206,5 @@ def test_tuple_width(self, wide_multi_index):
             ('abc', 10, '2000-01-01 00:33:17', '2000-01-01 00:33:17', ...),
             ('abc', 10, '2000-01-01 00:33:18', '2000-01-01 00:33:18', ...),
             ('abc', 10, '2000-01-01 00:33:19', '2000-01-01 00:33:19', ...)],
-           names=['a', 'b', 'dti_1', 'dti_2', 'dti_3'], length=2000)"""  # noqa
+           names=['a', 'b', 'dti_1', 'dti_2', 'dti_3'], length=2000)"""
         assert result == expected
diff --git a/pandas/tests/indexes/multi/test_sorting.py b/pandas/tests/indexes/multi/test_sorting.py
index 423bbed831b87..a1e5cc33ef2f6 100644
--- a/pandas/tests/indexes/multi/test_sorting.py
+++ b/pandas/tests/indexes/multi/test_sorting.py
@@ -119,7 +119,7 @@ def test_unsortedindex():
 
 
 def test_unsortedindex_doc_examples():
-    # https://pandas.pydata.org/pandas-docs/stable/advanced.html#sorting-a-multiindex  # noqa
+    # https://pandas.pydata.org/pandas-docs/stable/advanced.html#sorting-a-multiindex
     dfm = DataFrame(
         {"jim": [0, 0, 1, 1], "joe": ["x", "x", "z", "y"], "jolie": np.random.rand(4)}
     )
diff --git a/pandas/tests/indexing/test_callable.py b/pandas/tests/indexing/test_callable.py
index bf51c3e5d1695..b98c9a3df0438 100644
--- a/pandas/tests/indexing/test_callable.py
+++ b/pandas/tests/indexing/test_callable.py
@@ -17,11 +17,11 @@ def test_frame_loc_callable(self):
         res = df.loc[lambda x: x.A > 2]
         tm.assert_frame_equal(res, df.loc[df.A > 2])
 
-        res = df.loc[lambda x: x.A > 2]  # noqa: E231
-        tm.assert_frame_equal(res, df.loc[df.A > 2])  # noqa: E231
+        res = df.loc[lambda x: x.A > 2]
+        tm.assert_frame_equal(res, df.loc[df.A > 2])
 
-        res = df.loc[lambda x: x.A > 2]  # noqa: E231
-        tm.assert_frame_equal(res, df.loc[df.A > 2])  # noqa: E231
+        res = df.loc[lambda x: x.A > 2]
+        tm.assert_frame_equal(res, df.loc[df.A > 2])
 
         res = df.loc[lambda x: x.B == "b", :]
         tm.assert_frame_equal(res, df.loc[df.B == "b", :])
@@ -90,8 +90,8 @@ def test_frame_loc_callable_labels(self):
         res = df.loc[lambda x: ["A", "C"]]
         tm.assert_frame_equal(res, df.loc[["A", "C"]])
 
-        res = df.loc[lambda x: ["A", "C"]]  # noqa: E231
-        tm.assert_frame_equal(res, df.loc[["A", "C"]])  # noqa: E231
+        res = df.loc[lambda x: ["A", "C"]]
+        tm.assert_frame_equal(res, df.loc[["A", "C"]])
 
         res = df.loc[lambda x: ["A", "C"], :]
         tm.assert_frame_equal(res, df.loc[["A", "C"], :])
diff --git a/pandas/tests/io/formats/test_style.py b/pandas/tests/io/formats/test_style.py
index 8d66a16fc2b7a..476d75f7d239d 100644
--- a/pandas/tests/io/formats/test_style.py
+++ b/pandas/tests/io/formats/test_style.py
@@ -12,7 +12,7 @@
 import pandas._testing as tm
 
 jinja2 = pytest.importorskip("jinja2")
-from pandas.io.formats.style import Styler, _get_level_lengths  # noqa  # isort:skip
+from pandas.io.formats.style import Styler, _get_level_lengths  # isort:skip
 
 
 class TestStyler:
diff --git a/pandas/tests/io/json/test_pandas.py b/pandas/tests/io/json/test_pandas.py
index 9278e64cc911f..822342113f62a 100644
--- a/pandas/tests/io/json/test_pandas.py
+++ b/pandas/tests/io/json/test_pandas.py
@@ -987,7 +987,7 @@ def test_round_trip_exception_(self):
         ],
     )
     def test_url(self, field, dtype):
-        url = "https://api.github.com/repos/pandas-dev/pandas/issues?per_page=5"  # noqa
+        url = "https://api.github.com/repos/pandas-dev/pandas/issues?per_page=5"
         result = read_json(url, convert_dates=True)
         assert result[field].dtype == dtype
 
diff --git a/pandas/tests/io/parser/test_index_col.py b/pandas/tests/io/parser/test_index_col.py
index 9f425168540ba..4d64f2bf411bd 100644
--- a/pandas/tests/io/parser/test_index_col.py
+++ b/pandas/tests/io/parser/test_index_col.py
@@ -21,7 +21,7 @@ def test_index_col_named(all_parsers, with_header):
 KORD3,19990127, 21:00:00, 20:56:00, -0.5900, 2.2100, 5.7000, 0.0000, 280.0000
 KORD4,19990127, 21:00:00, 21:18:00, -0.9900, 2.0100, 3.6000, 0.0000, 270.0000
 KORD5,19990127, 22:00:00, 21:56:00, -0.5900, 1.7100, 5.1000, 0.0000, 290.0000
-KORD6,19990127, 23:00:00, 22:56:00, -0.5900, 1.7100, 4.6000, 0.0000, 280.0000"""  # noqa
+KORD6,19990127, 23:00:00, 22:56:00, -0.5900, 1.7100, 4.6000, 0.0000, 280.0000"""
     header = "ID,date,NominalTime,ActualTime,TDew,TAir,Windspeed,Precip,WindDir\n"
 
     if with_header:
diff --git a/pandas/tests/io/pytables/test_store.py b/pandas/tests/io/pytables/test_store.py
index ccb2efbd2c630..c1938db12a0bc 100644
--- a/pandas/tests/io/pytables/test_store.py
+++ b/pandas/tests/io/pytables/test_store.py
@@ -52,8 +52,8 @@
     read_hdf,
 )
 
-from pandas.io import pytables as pytables  # noqa: E402 isort:skip
-from pandas.io.pytables import TableIterator  # noqa: E402 isort:skip
+from pandas.io import pytables as pytables  # isort:skip
+from pandas.io.pytables import TableIterator  # isort:skip
 
 
 _default_compressor = "blosc"
@@ -512,7 +512,7 @@ def check(mode):
                 # context
                 if mode in ["r", "r+"]:
                     with pytest.raises(IOError):
-                        with HDFStore(path, mode=mode) as store:  # noqa
+                        with HDFStore(path, mode=mode) as store:
                             pass
                 else:
                     with HDFStore(path, mode=mode) as store:
@@ -2350,7 +2350,7 @@ def test_same_name_scoping(self, setup_path):
             store.put("df", df, format="table")
             expected = df[df.index > pd.Timestamp("20130105")]
 
-            import datetime  # noqa
+            import datetime
 
             result = store.select("df", "index>datetime.datetime(2013,1,5)")
             tm.assert_frame_equal(result, expected)
diff --git a/pandas/tests/io/test_feather.py b/pandas/tests/io/test_feather.py
index c1e63f512b53e..cef5d28b8ccf0 100644
--- a/pandas/tests/io/test_feather.py
+++ b/pandas/tests/io/test_feather.py
@@ -9,7 +9,7 @@
 import pandas as pd
 import pandas._testing as tm
 
-from pandas.io.feather_format import read_feather, to_feather  # noqa: E402 isort:skip
+from pandas.io.feather_format import read_feather, to_feather  # isort:skip
 
 pyarrow = pytest.importorskip("pyarrow")
 
diff --git a/pandas/tests/io/test_gcs.py b/pandas/tests/io/test_gcs.py
index 9d179d983ceeb..65e174cd32e22 100644
--- a/pandas/tests/io/test_gcs.py
+++ b/pandas/tests/io/test_gcs.py
@@ -14,7 +14,7 @@ def gcs_buffer(monkeypatch):
     """Emulate GCS using a binary buffer."""
     from fsspec import AbstractFileSystem, registry
 
-    registry.target.clear()  # noqa  # remove state
+    registry.target.clear()  # remove state
 
     gcs_buffer = BytesIO()
     gcs_buffer.close = lambda: True
@@ -33,7 +33,7 @@ def open(*args, **kwargs):
 def test_read_csv_gcs(gcs_buffer):
     from fsspec import registry
 
-    registry.target.clear()  # noqa  # remove state
+    registry.target.clear()  # remove state
 
     df1 = DataFrame(
         {
@@ -55,7 +55,7 @@ def test_read_csv_gcs(gcs_buffer):
 def test_to_csv_gcs(gcs_buffer):
     from fsspec import registry
 
-    registry.target.clear()  # noqa  # remove state
+    registry.target.clear()  # remove state
 
     df1 = DataFrame(
         {
@@ -84,7 +84,7 @@ def test_to_csv_compression_encoding_gcs(gcs_buffer, compression_only, encoding)
     """
     from fsspec import registry
 
-    registry.target.clear()  # noqa  # remove state
+    registry.target.clear()  # remove state
     df = tm.makeDataFrame()
 
     # reference of compressed and encoded file
@@ -120,7 +120,7 @@ def test_to_parquet_gcs_new_file(monkeypatch, tmpdir):
     """Regression test for writing to a not-yet-existent GCS Parquet file."""
     from fsspec import AbstractFileSystem, registry
 
-    registry.target.clear()  # noqa  # remove state
+    registry.target.clear()  # remove state
     df1 = DataFrame(
         {
             "int": [1, 3],
diff --git a/pandas/tests/io/test_parquet.py b/pandas/tests/io/test_parquet.py
index b7c8ca7e0c49f..f7b25f8c0eeac 100644
--- a/pandas/tests/io/test_parquet.py
+++ b/pandas/tests/io/test_parquet.py
@@ -24,14 +24,14 @@
 )
 
 try:
-    import pyarrow  # noqa
+    import pyarrow
 
     _HAVE_PYARROW = True
 except ImportError:
     _HAVE_PYARROW = False
 
 try:
-    import fastparquet  # noqa
+    import fastparquet
 
     _HAVE_FASTPARQUET = True
 except ImportError:
@@ -818,7 +818,7 @@ def test_partition_cols_supported(self, fp, df_full):
                 compression=None,
             )
             assert os.path.exists(path)
-            import fastparquet  # noqa: F811
+            import fastparquet
 
             actual_partition_cols = fastparquet.ParquetFile(path, False).cats
             assert len(actual_partition_cols) == 2
@@ -835,7 +835,7 @@ def test_partition_cols_string(self, fp, df_full):
                 compression=None,
             )
             assert os.path.exists(path)
-            import fastparquet  # noqa: F811
+            import fastparquet
 
             actual_partition_cols = fastparquet.ParquetFile(path, False).cats
             assert len(actual_partition_cols) == 1
@@ -852,7 +852,7 @@ def test_partition_on_supported(self, fp, df_full):
                 partition_on=partition_cols,
             )
             assert os.path.exists(path)
-            import fastparquet  # noqa: F811
+            import fastparquet
 
             actual_partition_cols = fastparquet.ParquetFile(path, False).cats
             assert len(actual_partition_cols) == 2
diff --git a/pandas/tests/plotting/test_frame.py b/pandas/tests/plotting/test_frame.py
index ca4c2bdcc2fe1..bdb86d2dd846f 100644
--- a/pandas/tests/plotting/test_frame.py
+++ b/pandas/tests/plotting/test_frame.py
@@ -3448,7 +3448,7 @@ def test_xlabel_ylabel_dataframe_subplots(
 
 def _generate_4_axes_via_gridspec():
     import matplotlib as mpl
-    import matplotlib.gridspec  # noqa
+    import matplotlib.gridspec
     import matplotlib.pyplot as plt
 
     gs = mpl.gridspec.GridSpec(2, 2)
diff --git a/pandas/tests/scalar/timestamp/test_constructors.py b/pandas/tests/scalar/timestamp/test_constructors.py
index d1c3ad508d877..583110cc4ba70 100644
--- a/pandas/tests/scalar/timestamp/test_constructors.py
+++ b/pandas/tests/scalar/timestamp/test_constructors.py
@@ -135,7 +135,7 @@ def test_constructor_with_stringoffset(self):
         # converted to Chicago tz
         result = Timestamp("2013-11-01 00:00:00-0500", tz="America/Chicago")
         assert result.value == Timestamp("2013-11-01 05:00").value
-        expected = "Timestamp('2013-11-01 00:00:00-0500', tz='America/Chicago')"  # noqa
+        expected = "Timestamp('2013-11-01 00:00:00-0500', tz='America/Chicago')"
         assert repr(result) == expected
         assert result == eval(repr(result))
 
diff --git a/pandas/tests/series/test_repr.py b/pandas/tests/series/test_repr.py
index 3aaecc37df56c..32e1220f83f40 100644
--- a/pandas/tests/series/test_repr.py
+++ b/pandas/tests/series/test_repr.py
@@ -486,7 +486,7 @@ def test_categorical_series_repr_timedelta_ordered(self):
 3   4 days
 4   5 days
 dtype: category
-Categories (5, timedelta64[ns]): [1 days < 2 days < 3 days < 4 days < 5 days]"""  # noqa
+Categories (5, timedelta64[ns]): [1 days < 2 days < 3 days < 4 days < 5 days]"""
 
         assert repr(s) == exp
 
diff --git a/pandas/tests/test_common.py b/pandas/tests/test_common.py
index f7f3f1fa0c13d..17d7527a2b687 100644
--- a/pandas/tests/test_common.py
+++ b/pandas/tests/test_common.py
@@ -21,7 +21,7 @@ def test_get_callable_name():
     def fn(x):
         return x
 
-    lambda_ = lambda x: x  # noqa: E731
+    lambda_ = lambda x: x
     part1 = partial(fn)
     part2 = partial(part1)
 
diff --git a/pandas/tests/test_downstream.py b/pandas/tests/test_downstream.py
index b32c5e91af295..c03e8e26952e5 100644
--- a/pandas/tests/test_downstream.py
+++ b/pandas/tests/test_downstream.py
@@ -20,7 +20,7 @@ def import_module(name):
 
     try:
         return importlib.import_module(name)
-    except ModuleNotFoundError:  # noqa
+    except ModuleNotFoundError:
         pytest.skip(f"skipping as {name} not available")
 
 
@@ -117,7 +117,7 @@ def test_pandas_gbq(df):
 @tm.network
 def test_pandas_datareader():
 
-    pandas_datareader = import_module("pandas_datareader")  # noqa
+    pandas_datareader = import_module("pandas_datareader")
     pandas_datareader.DataReader("F", "quandl", "2017-01-01", "2017-02-01")
 
 
@@ -125,7 +125,7 @@ def test_pandas_datareader():
 @pytest.mark.filterwarnings("ignore:can't resolve:ImportWarning")
 def test_geopandas():
 
-    geopandas = import_module("geopandas")  # noqa
+    geopandas = import_module("geopandas")
     fp = geopandas.datasets.get_path("naturalearth_lowres")
     assert geopandas.read_file(fp) is not None
 
@@ -135,7 +135,7 @@ def test_geopandas():
 @pytest.mark.filterwarnings("ignore:RangeIndex.* is deprecated:DeprecationWarning")
 def test_pyarrow(df):
 
-    pyarrow = import_module("pyarrow")  # noqa
+    pyarrow = import_module("pyarrow")
     table = pyarrow.Table.from_pandas(df)
     result = table.to_pandas()
     tm.assert_frame_equal(result, df)
diff --git a/pandas/tests/test_errors.py b/pandas/tests/test_errors.py
index 6a1a74c73288f..6207b886b95c7 100644
--- a/pandas/tests/test_errors.py
+++ b/pandas/tests/test_errors.py
@@ -2,7 +2,7 @@
 
 from pandas.errors import AbstractMethodError
 
-import pandas as pd  # noqa
+import pandas as pd
 
 
 @pytest.mark.parametrize(
diff --git a/scripts/validate_docstrings.py b/scripts/validate_docstrings.py
index 7971379ca60c1..8b15358834066 100755
--- a/scripts/validate_docstrings.py
+++ b/scripts/validate_docstrings.py
@@ -35,19 +35,19 @@
 # script. Setting here before matplotlib is loaded.
 # We don't warn for the number of open plots, as none is actually being opened
 os.environ["MPLBACKEND"] = "Template"
-import matplotlib  # noqa: E402 isort:skip
+import matplotlib  # isort:skip
 
 matplotlib.rc("figure", max_open_warning=10000)
 
-import numpy  # noqa: E402 isort:skip
+import numpy  # isort:skip
 
 BASE_PATH = os.path.dirname(os.path.dirname(os.path.abspath(__file__)))
 
 sys.path.insert(0, os.path.join(BASE_PATH))
-import pandas  # noqa: E402 isort:skip
+import pandas  # isort:skip
 
 sys.path.insert(1, os.path.join(BASE_PATH, "doc", "sphinxext"))
-from numpydoc.validate import validate, Docstring  # noqa: E402 isort:skip
+from numpydoc.validate import validate, Docstring  # isort:skip
 
 
 PRIVATE_CLASSES = ["NDFrame", "IndexOpsMixin"]
diff --git a/setup.py b/setup.py
index 8e25705c1f4c3..9a9d12ce4d2ba 100755
--- a/setup.py
+++ b/setup.py
@@ -51,8 +51,8 @@ def is_platform_mac():
 # The import of Extension must be after the import of Cython, otherwise
 # we do not get the appropriately patched class.
 # See https://cython.readthedocs.io/en/latest/src/userguide/source_files_and_compilation.html # noqa
-from distutils.extension import Extension  # noqa: E402 isort:skip
-from distutils.command.build import build  # noqa: E402 isort:skip
+from distutils.extension import Extension  # isort:skip
+from distutils.command.build import build  # isort:skip
 
 if _CYTHON_INSTALLED:
     from Cython.Distutils.old_build_ext import old_build_ext as _build_ext