diff --git a/doc/source/whatsnew/v1.1.0.rst b/doc/source/whatsnew/v1.1.0.rst
index f6ad3a800283d..90d90bc4cd445 100644
--- a/doc/source/whatsnew/v1.1.0.rst
+++ b/doc/source/whatsnew/v1.1.0.rst
@@ -1006,6 +1006,7 @@ Plotting
 - Bug in :meth:`DataFrame.hist` where the order of ``column`` argument was ignored (:issue:`29235`)
 - Bug in :meth:`DataFrame.plot.scatter` that when adding multiple plots with different ``cmap``, colorbars alway use the first ``cmap`` (:issue:`33389`)
 - Bug in :meth:`DataFrame.plot.scatter` was adding a colorbar to the plot even if the argument `c` was assigned to a column containing color names (:issue:`34316`)
+- Bug in :meth:`pandas.plotting.bootstrap_plot` was causing cluttered axes and overlapping labels (:issue:`34905`)
 
 Groupby/resample/rolling
 ^^^^^^^^^^^^^^^^^^^^^^^^
diff --git a/pandas/plotting/_matplotlib/misc.py b/pandas/plotting/_matplotlib/misc.py
index 0cafcfed38a54..bb6530b0f6412 100644
--- a/pandas/plotting/_matplotlib/misc.py
+++ b/pandas/plotting/_matplotlib/misc.py
@@ -301,6 +301,7 @@ def bootstrap_plot(series, fig=None, size=50, samples=500, **kwds):
     for axis in axes:
         plt.setp(axis.get_xticklabels(), fontsize=8)
         plt.setp(axis.get_yticklabels(), fontsize=8)
+    plt.tight_layout()
     return fig