diff --git a/pandas/core/indexing.py b/pandas/core/indexing.py
index 9c8b01003bece..4d5a9e54e7d37 100644
--- a/pandas/core/indexing.py
+++ b/pandas/core/indexing.py
@@ -1676,7 +1676,6 @@ def isetter(loc, v):
                     ser = v
                 else:
                     # set the item, possibly having a dtype change
-                    ser._consolidate_inplace()
                     ser = ser.copy()
                     ser._mgr = ser._mgr.setitem(indexer=pi, value=v)
                     ser._maybe_update_cacher(clear=True)