diff --git a/pandas/_libs/parsers.pyx b/pandas/_libs/parsers.pyx
index 3a42a64046abd..4f7d75e0aaad6 100644
--- a/pandas/_libs/parsers.pyx
+++ b/pandas/_libs/parsers.pyx
@@ -1596,8 +1596,6 @@ cdef _categorical_convert(parser_t *parser, int64_t col,
 cdef _to_fw_string(parser_t *parser, int64_t col, int64_t line_start,
                    int64_t line_end, int64_t width):
     cdef:
-        Py_ssize_t i
-        coliter_t it
         const char *word = NULL
         char *data
         ndarray result
@@ -1642,15 +1640,11 @@ cdef _try_double(parser_t *parser, int64_t col,
                  bint na_filter, kh_str_starts_t *na_hashset, object na_flist):
     cdef:
         int error, na_count = 0
-        Py_ssize_t i, lines
-        coliter_t it
-        const char *word = NULL
-        char *p_end
+        Py_ssize_t lines
         float64_t *data
         float64_t NA = na_values[np.float64]
         kh_float64_t *na_fset
         ndarray result
-        khiter_t k
         bint use_na_flist = len(na_flist) > 0
 
     lines = line_end - line_start
@@ -1685,7 +1679,7 @@ cdef inline int _try_double_nogil(parser_t *parser,
         coliter_t it
         const char *word = NULL
         char *p_end
-        khiter_t k, k64
+        khiter_t k64
 
     na_count[0] = 0
     coliter_setup(&it, parser, col, line_start)
@@ -1748,11 +1742,10 @@ cdef _try_uint64(parser_t *parser, int64_t col,
                  bint na_filter, kh_str_starts_t *na_hashset):
     cdef:
         int error
-        Py_ssize_t i, lines
+        Py_ssize_t lines
         coliter_t it
         uint64_t *data
         ndarray result
-        khiter_t k
         uint_state state
 
     lines = line_end - line_start
@@ -1822,13 +1815,11 @@ cdef _try_int64(parser_t *parser, int64_t col,
                 bint na_filter, kh_str_starts_t *na_hashset):
     cdef:
         int error, na_count = 0
-        Py_ssize_t i, lines
+        Py_ssize_t lines
         coliter_t it
         int64_t *data
         ndarray result
-
         int64_t NA = na_values[np.int64]
-        khiter_t k
 
     lines = line_end - line_start
     result = np.empty(lines, dtype=np.int64)
@@ -1856,7 +1847,6 @@ cdef inline int _try_int64_nogil(parser_t *parser, int64_t col,
         Py_ssize_t i, lines = line_end - line_start
         coliter_t it
         const char *word = NULL
-        khiter_t k
 
     na_count[0] = 0
     coliter_setup(&it, parser, col, line_start)
@@ -1892,9 +1882,7 @@ cdef _try_bool_flex(parser_t *parser, int64_t col,
                     const kh_str_starts_t *false_hashset):
     cdef:
         int error, na_count = 0
-        Py_ssize_t i, lines
-        coliter_t it
-        const char *word = NULL
+        Py_ssize_t lines
         uint8_t *data
         ndarray result
 
@@ -1926,7 +1914,6 @@ cdef inline int _try_bool_flex_nogil(parser_t *parser, int64_t col,
         Py_ssize_t i, lines = line_end - line_start
         coliter_t it
         const char *word = NULL
-        khiter_t k
 
     na_count[0] = 0
     coliter_setup(&it, parser, col, line_start)
@@ -1981,10 +1968,8 @@ cdef kh_str_starts_t* kset_from_list(list values) except NULL:
     # caller takes responsibility for freeing the hash table
     cdef:
         Py_ssize_t i
-        khiter_t k
         kh_str_starts_t *table
         int ret = 0
-
         object val
 
     table = kh_init_str_starts()
@@ -2012,7 +1997,6 @@ cdef kh_str_starts_t* kset_from_list(list values) except NULL:
 cdef kh_float64_t* kset_float64_from_list(values) except NULL:
     # caller takes responsibility for freeing the hash table
     cdef:
-        Py_ssize_t i
         khiter_t k
         kh_float64_t *table
         int ret = 0
@@ -2150,7 +2134,6 @@ cdef _apply_converter(object f, parser_t *parser, int64_t col,
                       int64_t line_start, int64_t line_end,
                       char* c_encoding):
     cdef:
-        int error
         Py_ssize_t i, lines
         coliter_t it
         const char *word = NULL