diff --git a/pandas/tests/indexing/multiindex/test_slice.py b/pandas/tests/indexing/multiindex/test_slice.py
index f1f11285696f9..f279b5517c3f6 100644
--- a/pandas/tests/indexing/multiindex/test_slice.py
+++ b/pandas/tests/indexing/multiindex/test_slice.py
@@ -492,6 +492,44 @@ def test_loc_axis_arguments(self):
         with pytest.raises(ValueError):
             df.loc(axis="foo")[:, :, ["C1", "C3"]]
 
+    def test_loc_axis_single_level_multi_col_indexing_multiindex_col_df(self):
+
+        # GH29519
+        df = pd.DataFrame(
+            np.arange(27).reshape(3, 9),
+            columns=pd.MultiIndex.from_product(
+                [["a1", "a2", "a3"], ["b1", "b2", "b3"]]
+            ),
+        )
+        result = df.loc(axis=1)["a1":"a2"]
+        expected = df.iloc[:, :-3]
+
+        tm.assert_frame_equal(result, expected)
+
+    def test_loc_axis_single_level_single_col_indexing_multiindex_col_df(self):
+
+        # GH29519
+        df = pd.DataFrame(
+            np.arange(27).reshape(3, 9),
+            columns=pd.MultiIndex.from_product(
+                [["a1", "a2", "a3"], ["b1", "b2", "b3"]]
+            ),
+        )
+        result = df.loc(axis=1)["a1"]
+        expected = df.iloc[:, :3]
+        expected.columns = ["b1", "b2", "b3"]
+
+        tm.assert_frame_equal(result, expected)
+
+    def test_loc_ax_single_level_indexer_simple_df(self):
+
+        # GH29519
+        # test single level indexing on single index column data frame
+        df = pd.DataFrame(np.arange(9).reshape(3, 3), columns=["a", "b", "c"])
+        result = df.loc(axis=1)["a"]
+        expected = pd.Series(np.array([0, 3, 6]), name="a")
+        tm.assert_series_equal(result, expected)
+
     def test_per_axis_per_level_setitem(self):
 
         # test index maker