diff --git a/setup.cfg b/setup.cfg
index 62d9f2e6056bb..c7d3394568f9c 100644
--- a/setup.cfg
+++ b/setup.cfg
@@ -122,6 +122,10 @@ skip = pandas/__init__.py,pandas/core/api.py
 [mypy]
 ignore_missing_imports=True
 no_implicit_optional=True
+check_untyped_defs=True
+
+[mypy-pandas.tests.*]
+check_untyped_defs=False
 
 [mypy-pandas.conftest]
 ignore_errors=True
@@ -143,3 +147,228 @@ ignore_errors=True
 
 [mypy-pandas.tests.scalar.period.test_period]
 ignore_errors=True
+
+[mypy-pandas._version]
+check_untyped_defs=False
+
+[mypy-pandas.core.arrays.boolean]
+check_untyped_defs=False
+
+[mypy-pandas.core.arrays.categorical]
+check_untyped_defs=False
+
+[mypy-pandas.core.arrays.integer]
+check_untyped_defs=False
+
+[mypy-pandas.core.arrays.interval]
+check_untyped_defs=False
+
+[mypy-pandas.core.arrays.sparse.array]
+check_untyped_defs=False
+
+[mypy-pandas.core.base]
+check_untyped_defs=False
+
+[mypy-pandas.core.computation.align]
+check_untyped_defs=False
+
+[mypy-pandas.core.computation.eval]
+check_untyped_defs=False
+
+[mypy-pandas.core.computation.expr]
+check_untyped_defs=False
+
+[mypy-pandas.core.computation.expressions]
+check_untyped_defs=False
+
+[mypy-pandas.core.computation.ops]
+check_untyped_defs=False
+
+[mypy-pandas.core.computation.pytables]
+check_untyped_defs=False
+
+[mypy-pandas.core.computation.scope]
+check_untyped_defs=False
+
+[mypy-pandas.core.config_init]
+check_untyped_defs=False
+
+[mypy-pandas.core.dtypes.cast]
+check_untyped_defs=False
+
+[mypy-pandas.core.dtypes.generic]
+check_untyped_defs=False
+
+[mypy-pandas.core.frame]
+check_untyped_defs=False
+
+[mypy-pandas.core.generic]
+check_untyped_defs=False
+
+[mypy-pandas.core.groupby.generic]
+check_untyped_defs=False
+
+[mypy-pandas.core.groupby.grouper]
+check_untyped_defs=False
+
+[mypy-pandas.core.groupby.ops]
+check_untyped_defs=False
+
+[mypy-pandas.core.indexes.base]
+check_untyped_defs=False
+
+[mypy-pandas.core.indexes.category]
+check_untyped_defs=False
+
+[mypy-pandas.core.indexes.datetimelike]
+check_untyped_defs=False
+
+[mypy-pandas.core.indexes.datetimes]
+check_untyped_defs=False
+
+[mypy-pandas.core.indexes.interval]
+check_untyped_defs=False
+
+[mypy-pandas.core.indexes.multi]
+check_untyped_defs=False
+
+[mypy-pandas.core.indexes.timedeltas]
+check_untyped_defs=False
+
+[mypy-pandas.core.indexing]
+check_untyped_defs=False
+
+[mypy-pandas.core.internals.blocks]
+check_untyped_defs=False
+
+[mypy-pandas.core.internals.concat]
+check_untyped_defs=False
+
+[mypy-pandas.core.internals.construction]
+check_untyped_defs=False
+
+[mypy-pandas.core.internals.managers]
+check_untyped_defs=False
+
+[mypy-pandas.core.missing]
+check_untyped_defs=False
+
+[mypy-pandas.core.nanops]
+check_untyped_defs=False
+
+[mypy-pandas.core.ops.docstrings]
+check_untyped_defs=False
+
+[mypy-pandas.core.resample]
+check_untyped_defs=False
+
+[mypy-pandas.core.reshape.merge]
+check_untyped_defs=False
+
+[mypy-pandas.core.reshape.reshape]
+check_untyped_defs=False
+
+[mypy-pandas.core.series]
+check_untyped_defs=False
+
+[mypy-pandas.core.strings]
+check_untyped_defs=False
+
+[mypy-pandas.core.tools.datetimes]
+check_untyped_defs=False
+
+[mypy-pandas.core.window.common]
+check_untyped_defs=False
+
+[mypy-pandas.core.window.ewm]
+check_untyped_defs=False
+
+[mypy-pandas.core.window.expanding]
+check_untyped_defs=False
+
+[mypy-pandas.core.window.rolling]
+check_untyped_defs=False
+
+[mypy-pandas.io.clipboard]
+check_untyped_defs=False
+
+[mypy-pandas.io.excel._base]
+check_untyped_defs=False
+
+[mypy-pandas.io.excel._openpyxl]
+check_untyped_defs=False
+
+[mypy-pandas.io.excel._util]
+check_untyped_defs=False
+
+[mypy-pandas.io.excel._xlwt]
+check_untyped_defs=False
+
+[mypy-pandas.io.formats.console]
+check_untyped_defs=False
+
+[mypy-pandas.io.formats.css]
+check_untyped_defs=False
+
+[mypy-pandas.io.formats.excel]
+check_untyped_defs=False
+
+[mypy-pandas.io.formats.format]
+check_untyped_defs=False
+
+[mypy-pandas.io.formats.style]
+check_untyped_defs=False
+
+[mypy-pandas.io.html]
+check_untyped_defs=False
+
+[mypy-pandas.io.json._json]
+check_untyped_defs=False
+
+[mypy-pandas.io.json._normalize]
+check_untyped_defs=False
+
+[mypy-pandas.io.json._table_schema]
+check_untyped_defs=False
+
+[mypy-pandas.io.parsers]
+check_untyped_defs=False
+
+[mypy-pandas.io.pytables]
+check_untyped_defs=False
+
+[mypy-pandas.io.sas.sas_xport]
+check_untyped_defs=False
+
+[mypy-pandas.io.sas.sas7bdat]
+check_untyped_defs=False
+
+[mypy-pandas.io.sas.sasreader]
+check_untyped_defs=False
+
+[mypy-pandas.io.sql]
+check_untyped_defs=False
+
+[mypy-pandas.io.stata]
+check_untyped_defs=False
+
+[mypy-pandas.plotting._matplotlib.converter]
+check_untyped_defs=False
+
+[mypy-pandas.plotting._matplotlib.core]
+check_untyped_defs=False
+
+[mypy-pandas.plotting._matplotlib.misc]
+check_untyped_defs=False
+
+[mypy-pandas.plotting._matplotlib.timeseries]
+check_untyped_defs=False
+
+[mypy-pandas.tseries.holiday]
+check_untyped_defs=False
+
+[mypy-pandas.tseries.offsets]
+check_untyped_defs=False
+
+[mypy-pandas.util.testing]
+check_untyped_defs=False