diff --git a/pandas/tests/tools/test_numeric.py b/pandas/tests/tools/test_numeric.py
index 55f83e492e2cc..082277796e602 100644
--- a/pandas/tests/tools/test_numeric.py
+++ b/pandas/tests/tools/test_numeric.py
@@ -567,6 +567,24 @@ def test_downcast_limits(dtype, downcast, min_max):
     assert series.dtype == dtype
 
 
+@pytest.mark.parametrize(
+    "ser,expected",
+    [
+        (
+            pd.Series([0, 9223372036854775808]),
+            pd.Series([0, 9223372036854775808], dtype=np.uint64),
+        )
+    ],
+)
+def test_downcast_uint64(ser, expected):
+    # see gh-14422:
+    # BUG: to_numeric doesn't work uint64 numbers
+
+    result = pd.to_numeric(ser, downcast="unsigned")
+
+    tm.assert_series_equal(result, expected)
+
+
 @pytest.mark.parametrize(
     "data,exp_data",
     [