diff --git a/pandas/core/groupby/grouper.py b/pandas/core/groupby/grouper.py
index 818d844ca7994..3cf358261e685 100644
--- a/pandas/core/groupby/grouper.py
+++ b/pandas/core/groupby/grouper.py
@@ -284,7 +284,7 @@ def __init__(
             if self.name is None:
                 self.name = index.names[level]
 
-            self.grouper, self._labels, self._group_index = index._get_grouper_for_level(
+            self.grouper, self._labels, self._group_index = index._get_grouper_for_level(  # noqa: E501
                 self.grouper, level
             )
 
diff --git a/pandas/core/indexing.py b/pandas/core/indexing.py
index e27f85eb6d0a4..612a857897a0c 100755
--- a/pandas/core/indexing.py
+++ b/pandas/core/indexing.py
@@ -1230,8 +1230,8 @@ def _validate_read_indexer(self, key, indexer, axis, raise_missing=False):
             KeyError in the future, you can use .reindex() as an alternative.
 
             See the documentation here:
-            https://pandas.pydata.org/pandas-docs/stable/user_guide/indexing.html#deprecate-loc-reindex-listlike"""
-            )  # noqa
+            https://pandas.pydata.org/pandas-docs/stable/user_guide/indexing.html#deprecate-loc-reindex-listlike"""  # noqa: E501
+            )
 
             if not (ax.is_categorical() or ax.is_interval()):
                 warnings.warn(_missing_key_warning, FutureWarning, stacklevel=6)
@@ -1379,8 +1379,8 @@ class _IXIndexer(_NDFrameIndexer):
         .iloc for positional indexing
 
         See the documentation here:
-        http://pandas.pydata.org/pandas-docs/stable/user_guide/indexing.html#ix-indexer-is-deprecated"""
-    )  # noqa
+        http://pandas.pydata.org/pandas-docs/stable/user_guide/indexing.html#ix-indexer-is-deprecated"""  # noqa: E501
+    )
 
     def __init__(self, name, obj):
         warnings.warn(self._ix_deprecation_warning, FutureWarning, stacklevel=2)
diff --git a/pandas/io/parsers.py b/pandas/io/parsers.py
index 78440939ebc01..356934d457cc9 100755
--- a/pandas/io/parsers.py
+++ b/pandas/io/parsers.py
@@ -1913,7 +1913,7 @@ def __init__(self, src, **kwds):
         else:
             if len(self._reader.header) > 1:
                 # we have a multi index in the columns
-                self.names, self.index_names, self.col_names, passed_names = self._extract_multi_indexer_columns(
+                self.names, self.index_names, self.col_names, passed_names = self._extract_multi_indexer_columns(  # noqa: E501
                     self._reader.header, self.index_names, self.col_names, passed_names
                 )
             else:
@@ -2308,7 +2308,7 @@ def __init__(self, f, **kwds):
         # The original set is stored in self.original_columns.
         if len(self.columns) > 1:
             # we are processing a multi index column
-            self.columns, self.index_names, self.col_names, _ = self._extract_multi_indexer_columns(
+            self.columns, self.index_names, self.col_names, _ = self._extract_multi_indexer_columns(  # noqa: E501
                 self.columns, self.index_names, self.col_names
             )
             # Update list of original names to include all indices.
diff --git a/pandas/tests/io/json/test_normalize.py b/pandas/tests/io/json/test_normalize.py
index a32103d7b29b9..a625c912d1d8e 100644
--- a/pandas/tests/io/json/test_normalize.py
+++ b/pandas/tests/io/json/test_normalize.py
@@ -684,7 +684,7 @@ def test_with_large_max_level(self):
                 "CreatedBy.user.family_tree.father.name": "Father001",
                 "CreatedBy.user.family_tree.father.father.Name": "Father002",
                 "CreatedBy.user.family_tree.father.father.father.name": "Father003",
-                "CreatedBy.user.family_tree.father.father.father.father.Name": "Father004",
+                "CreatedBy.user.family_tree.father.father.father.father.Name": "Father004",  # noqa: E501
             }
         ]
         output = nested_to_record(input_data, max_level=max_level)
diff --git a/pandas/tests/util/test_hashing.py b/pandas/tests/util/test_hashing.py
index 27a23180b269a..df3c7fe9c9936 100644
--- a/pandas/tests/util/test_hashing.py
+++ b/pandas/tests/util/test_hashing.py
@@ -338,9 +338,9 @@ def test_hash_collisions():
     #
     # https://github.com/pandas-dev/pandas/issues/14711#issuecomment-264885726
     hashes = [
-        "Ingrid-9Z9fKIZmkO7i7Cn51Li34pJm44fgX6DYGBNj3VPlOH50m7HnBlPxfIwFMrcNJNMP6PSgLmwWnInciMWrCSAlLEvt7JkJl4IxiMrVbXSa8ZQoVaq5xoQPjltuJEfwdNlO6jo8qRRHvD8sBEBMQASrRa6TsdaPTPCBo3nwIBpE7YzzmyH0vMBhjQZLx1aCT7faSEx7PgFxQhHdKFWROcysamgy9iVj8DO2Fmwg1NNl93rIAqC3mdqfrCxrzfvIY8aJdzin2cHVzy3QUJxZgHvtUtOLxoqnUHsYbNTeq0xcLXpTZEZCxD4PGubIuCNf32c33M7HFsnjWSEjE2yVdWKhmSVodyF8hFYVmhYnMCztQnJrt3O8ZvVRXd5IKwlLexiSp4h888w7SzAIcKgc3g5XQJf6MlSMftDXm9lIsE1mJNiJEv6uY6pgvC3fUPhatlR5JPpVAHNSbSEE73MBzJrhCAbOLXQumyOXigZuPoME7QgJcBalliQol7YZ9",  # noqa
-        "Tim-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",
-    ]  # noqa
+        "Ingrid-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",  # noqa: E501
+        "Tim-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",  # noqa: E501
+    ]
 
     # These should be different.
     result1 = hash_array(np.asarray(hashes[0:1], dtype=object), "utf8")
diff --git a/setup.cfg b/setup.cfg
index 7549bfe2e325d..e559ece2a759a 100644
--- a/setup.cfg
+++ b/setup.cfg
@@ -14,7 +14,6 @@ parentdir_prefix = pandas-
 [flake8]
 max-line-length = 88
 ignore =
-    E501,  # longer line length
     E203,  # space before : (needed for how black formats slicing)
     W503,  # line break before binary operator
     W504,  # line break after binary operator