diff --git a/ci/deps/azure-35-compat.yaml b/ci/deps/azure-35-compat.yaml
index fe207d122657b..97c45b2be27d7 100644
--- a/ci/deps/azure-35-compat.yaml
+++ b/ci/deps/azure-35-compat.yaml
@@ -11,7 +11,7 @@ dependencies:
   - openpyxl=2.4.8
   - pytables=3.4.2
   - python-dateutil=2.6.1
-  - python=3.5.*
+  - python=3.5.3
   - pytz=2017.2
   - scipy=0.19.0
   - xlrd=1.1.0
diff --git a/doc/source/whatsnew/v0.25.0.rst b/doc/source/whatsnew/v0.25.0.rst
index 008f6f0b8643e..99dde5daa972d 100644
--- a/doc/source/whatsnew/v0.25.0.rst
+++ b/doc/source/whatsnew/v0.25.0.rst
@@ -5,9 +5,13 @@ What's new in 0.25.0 (April XX, 2019)
 
 .. warning::
 
-   Starting with the 0.25.x series of releases, pandas only supports Python 3.5 and higher.
+   Starting with the 0.25.x series of releases, pandas only supports Python 3.5.3 and higher.
    See :ref:`install.dropping-27` for more details.
 
+.. warning::
+
+   The minimum supported Python version will be bumped to 3.6 in a future release.
+
 .. warning::
 
    `Panel` has been fully removed. For N-D labeled data structures, please
diff --git a/setup.py b/setup.py
index 0380c717ecb41..19c22fc25733d 100755
--- a/setup.py
+++ b/setup.py
@@ -783,7 +783,7 @@ def srcpath(name=None, suffix='.pyx', subdir='src'):
       long_description=LONG_DESCRIPTION,
       classifiers=CLASSIFIERS,
       platforms='any',
-      python_requires='>=3.5',
+      python_requires='>=3.5.3',
       extras_require={
           'test': [
               # sync with setup.cfg minversion & install.rst