diff --git a/doc/source/whatsnew/v0.25.0.rst b/doc/source/whatsnew/v0.25.0.rst
index 49b2349851479..3ec6426cdb877 100644
--- a/doc/source/whatsnew/v0.25.0.rst
+++ b/doc/source/whatsnew/v0.25.0.rst
@@ -229,6 +229,7 @@ Bug Fixes
 ~~~~~~~~~
 
 
+
 Categorical
 ^^^^^^^^^^^
 
@@ -268,7 +269,7 @@ Numeric
 - Bug in error messages in :meth:`DataFrame.corr` and :meth:`Series.corr`. Added the possibility of using a callable. (:issue:`25729`)
 - Bug in :meth:`Series.divmod` and :meth:`Series.rdivmod` which would raise an (incorrect) ``ValueError`` rather than return a pair of :class:`Series` objects as result (:issue:`25557`)
 - Raises a helpful exception when a non-numeric index is sent to :meth:`interpolate` with methods which require numeric index. (:issue:`21662`)
--
+- Bug in :meth:`~pandas.eval` when comparing floats with scalar operators, for example: ``x < -0.1`` (:issue:`25928`)
 -
 
 
diff --git a/pandas/core/computation/expr.py b/pandas/core/computation/expr.py
index 16795ea8c58e9..0488d27d89be4 100644
--- a/pandas/core/computation/expr.py
+++ b/pandas/core/computation/expr.py
@@ -418,11 +418,13 @@ def _maybe_transform_eq_ne(self, node, left=None, right=None):
 
     def _maybe_downcast_constants(self, left, right):
         f32 = np.dtype(np.float32)
-        if left.is_scalar and not right.is_scalar and right.return_type == f32:
+        if (left.is_scalar and hasattr(left, 'value') and
+                not right.is_scalar and right.return_type == f32):
             # right is a float32 array, left is a scalar
             name = self.env.add_tmp(np.float32(left.value))
             left = self.term_type(name, self.env)
-        if right.is_scalar and not left.is_scalar and left.return_type == f32:
+        if (right.is_scalar and hasattr(right, 'value') and
+                not left.is_scalar and left.return_type == f32):
             # left is a float32 array, right is a scalar
             name = self.env.add_tmp(np.float32(right.value))
             right = self.term_type(name, self.env)
diff --git a/pandas/tests/computation/test_eval.py b/pandas/tests/computation/test_eval.py
index f2d5069ccb5d0..3908a7f1f99aa 100644
--- a/pandas/tests/computation/test_eval.py
+++ b/pandas/tests/computation/test_eval.py
@@ -608,6 +608,16 @@ def test_unary_in_array(self):
                       -False, False, ~False, +False,
                       -37, 37, ~37, +37], dtype=np.object_))
 
+    @pytest.mark.parametrize('dtype', [np.float32, np.float64])
+    def test_float_comparison_bin_op(self, dtype):
+        # GH 16363
+        df = pd.DataFrame({'x': np.array([0], dtype=dtype)})
+        res = df.eval('x < -0.1')
+        assert res.values == np.array([False])
+
+        res = df.eval('-5 > x')
+        assert res.values == np.array([False])
+
     def test_disallow_scalar_bool_ops(self):
         exprs = '1 or 2', '1 and 2'
         exprs += 'a and b', 'a or b'