diff --git a/pandas/core/frame.py b/pandas/core/frame.py
index ade05ab27093e..37ee3f7fbb74f 100644
--- a/pandas/core/frame.py
+++ b/pandas/core/frame.py
@@ -4615,7 +4615,7 @@ def dropna(self, axis=0, how='any', thresh=None, subset=None,
                 else:
                     raise TypeError('must specify how or thresh')
 
-            result = self.loc(axis=axis)[mask]
+            result = self.loc(axis=axis)[mask.to_numpy()]
 
         if inplace:
             self._update_inplace(result)