diff --git a/pandas/core/indexing.py b/pandas/core/indexing.py
index ab4ad693a462e..43d453153febd 100755
--- a/pandas/core/indexing.py
+++ b/pandas/core/indexing.py
@@ -630,6 +630,17 @@ def can_do_equal_len():
                     self.obj[item_labels[indexer[info_axis]]] = value
                     return
 
+                if isinstance(value, ABCDataFrame):
+                    if (len(indexer) > info_axis and
+                            (is_integer(indexer[info_axis]) or
+                                isinstance(indexer[info_axis], np.ndarray)) and
+                            all(com.is_null_slice(idx)
+                                for i, idx in enumerate(indexer)
+                                if i != info_axis) and
+                            item_labels.is_unique):
+                        self.obj[item_labels[indexer[info_axis]]] = value
+                        return
+
             if isinstance(value, (ABCSeries, dict)):
                 # TODO(EA): ExtensionBlock.setitem this causes issues with
                 # setting for extensionarrays that store dicts. Need to decide