diff --git a/pandas/_libs/reshape.pyx b/pandas/_libs/reshape.pyx
index db2e8b43d1ead..c4104b66e009f 100644
--- a/pandas/_libs/reshape.pyx
+++ b/pandas/_libs/reshape.pyx
@@ -10,7 +10,7 @@ np.import_array()
 
 from numpy cimport (ndarray,
                     int8_t, int16_t, int32_t, int64_t, uint8_t, uint16_t,
-                    uint32_t, uint64_t, float16_t, float32_t, float64_t)
+                    uint32_t, uint64_t, float32_t, float64_t)
 
 cdef double NaN = <double> np.NaN
 cdef double nan = NaN
diff --git a/pandas/_libs/sparse.pyx b/pandas/_libs/sparse.pyx
index 5484cbda5bdf9..bbdd5f0d8334c 100644
--- a/pandas/_libs/sparse.pyx
+++ b/pandas/_libs/sparse.pyx
@@ -1,5 +1,5 @@
 from numpy cimport (ndarray, uint8_t, int64_t, int32_t, int16_t, int8_t,
-                    float64_t, float32_t, float16_t)
+                    float64_t, float32_t)
 cimport numpy as np
 
 cimport cython
diff --git a/setup.py b/setup.py
index c3e0c037625da..80d4fb4a0a067 100755
--- a/setup.py
+++ b/setup.py
@@ -461,6 +461,13 @@ def pxd(name):
     return os.path.abspath(pjoin('pandas', name + '.pxd'))
 
 
+if _have_setuptools:
+    # Note: this is a list, whereas `numpy_incl` in build_ext.build_extensions
+    # is a string
+    numpy_incls = [pkg_resources.resource_filename('numpy', 'core/include')]
+else:
+    numpy_incls = []
+
 # args to ignore warnings
 if is_platform_windows():
     extra_compile_args = []
@@ -503,7 +510,8 @@ def pxd(name):
         'depends': _pxi_dep['index'],
         'sources': np_datetime_sources},
     '_libs.indexing': {
-        'pyxfile': '_libs/indexing'},
+        'pyxfile': '_libs/indexing',
+        'include': []},
     '_libs.interval': {
         'pyxfile': '_libs/interval',
         'pxdfiles': ['_libs/hashtable'],
@@ -536,10 +544,12 @@ def pxd(name):
         'include': []},
     '_libs.reshape': {
         'pyxfile': '_libs/reshape',
-        'depends': _pxi_dep['reshape']},
+        'depends': _pxi_dep['reshape'],
+        'include': numpy_incls},
     '_libs.sparse': {
         'pyxfile': '_libs/sparse',
-        'depends': _pxi_dep['sparse']},
+        'depends': _pxi_dep['sparse'],
+        'include': numpy_incls},
     '_libs.tslib': {
         'pyxfile': '_libs/tslib',
         'pxdfiles': ['_libs/src/util',
@@ -579,8 +589,7 @@ def pxd(name):
                      '_libs/tslibs/frequencies']},
     '_libs.tslibs.parsing': {
         'pyxfile': '_libs/tslibs/parsing',
-        'pxdfiles': ['_libs/src/util',
-                     '_libs/src/khash']},
+        'include': numpy_incls},
     '_libs.tslibs.resolution': {
         'pyxfile': '_libs/tslibs/resolution',
         'pxdfiles': ['_libs/src/util',
@@ -604,14 +613,16 @@ def pxd(name):
         'pyxfile': '_libs/tslibs/timezones',
         'pxdfiles': ['_libs/src/util']},
     '_libs.testing': {
-        'pyxfile': '_libs/testing'},
+        'pyxfile': '_libs/testing',
+        'include': []},
     '_libs.window': {
         'pyxfile': '_libs/window',
         'pxdfiles': ['_libs/src/skiplist', '_libs/src/util'],
         'depends': ['pandas/_libs/src/skiplist.pyx',
                     'pandas/_libs/src/skiplist.h']},
     'io.sas._sas': {
-        'pyxfile': 'io/sas/sas'}}
+        'pyxfile': 'io/sas/sas',
+        'include': numpy_incls}}
 
 extensions = []