diff --git a/doc/source/whatsnew/v0.19.0.txt b/doc/source/whatsnew/v0.19.0.txt
index 7f471904acf30..a391691a7550a 100644
--- a/doc/source/whatsnew/v0.19.0.txt
+++ b/doc/source/whatsnew/v0.19.0.txt
@@ -1478,3 +1478,4 @@ Bug Fixes
 
 - Bug in ``eval()`` where the ``resolvers`` argument would not accept a list (:issue:`14095`)
 - Bugs in ``stack``, ``get_dummies``, ``make_axis_dummies`` which don't preserve categorical dtypes in (multi)indexes (:issue:`13854`)
+- Bug in ```Series``` of ```np.timedelta64``` when setting a slice using an indexer   (:issue:`14155`)
diff --git a/pandas/core/internals.py b/pandas/core/internals.py
index bb2d1a9d1b5d3..f2df949a90585 100644
--- a/pandas/core/internals.py
+++ b/pandas/core/internals.py
@@ -1696,7 +1696,7 @@ def _try_coerce_args(self, values, other):
             other = other.value
         elif isinstance(other, np.timedelta64):
             other_mask = isnull(other)
-            other = other.view('i8')
+            other = Timedelta(other).value
         elif isinstance(other, timedelta):
             other = Timedelta(other).value
         elif isinstance(other, np.ndarray):
diff --git a/pandas/tests/series/test_indexing.py b/pandas/tests/series/test_indexing.py
index 64ebaa63cc10f..abeede16891ab 100644
--- a/pandas/tests/series/test_indexing.py
+++ b/pandas/tests/series/test_indexing.py
@@ -1324,6 +1324,13 @@ def test_timedelta_assignment(self):
         s.loc['A'] = timedelta(1)
         tm.assert_series_equal(s, expected)
 
+        # GH 14155
+        s = Series(10 * [np.timedelta64(10, 'm')])
+        s.loc[[1, 2, 3]] = np.timedelta64(20, 'm')
+        expected = pd.Series(10 * [np.timedelta64(10, 'm')])
+        expected.loc[[1, 2, 3]] = pd.Timedelta(np.timedelta64(20, 'm'))
+        tm.assert_series_equal(s, expected)
+
     def test_underlying_data_conversion(self):
 
         # GH 4080