diff --git a/doc/source/whatsnew/v0.19.0.txt b/doc/source/whatsnew/v0.19.0.txt
index 06625e09d70a1..326e124c2f03e 100644
--- a/doc/source/whatsnew/v0.19.0.txt
+++ b/doc/source/whatsnew/v0.19.0.txt
@@ -673,6 +673,7 @@ Performance Improvements
 Bug Fixes
 ~~~~~~~~~
 
+- Bug in ``pd.read_csv()``, which may cause a segfault or corruption when iterating in large chunks over a stream/file under rare circumstances (:issue:`13703`)
 - Bug in ``io.json.json_normalize()``, where non-ascii keys raised an exception (:issue:`13213`)
 - Bug in ``SparseSeries`` with ``MultiIndex`` ``[]`` indexing may raise ``IndexError`` (:issue:`13144`)
 - Bug in ``SparseSeries`` with ``MultiIndex`` ``[]`` indexing result may have normal ``Index`` (:issue:`13144`)
diff --git a/pandas/io/tests/parser/c_parser_only.py b/pandas/io/tests/parser/c_parser_only.py
index b6048051edc4d..103c9fa2b7ce8 100644
--- a/pandas/io/tests/parser/c_parser_only.py
+++ b/pandas/io/tests/parser/c_parser_only.py
@@ -381,3 +381,73 @@ def test_empty_header_read(count):
 
         for count in range(1, 101):
             test_empty_header_read(count)
+
+    def test_parse_trim_buffers(self):
+        # This test is part of a bugfix for issue #13703. It attmepts to
+        # to stress the system memory allocator, to cause it to move the
+        # stream buffer and either let the OS reclaim the region, or let
+        # other memory requests of parser otherwise modify the contents
+        # of memory space, where it was formely located.
+        # This test is designed to cause a `segfault` with unpatched
+        # `tokenizer.c`. Sometimes the test fails on `segfault`, other
+        # times it fails due to memory corruption, which causes the
+        # loaded DataFrame to differ from the expected one.
+
+        # Generate a large mixed-type CSV file on-the-fly (one record is
+        # approx 1.5KiB).
+        record_ = \
+            """9999-9,99:99,,,,ZZ,ZZ,,,ZZZ-ZZZZ,.Z-ZZZZ,-9.99,,,9.99,Z""" \
+            """ZZZZ,,-99,9,ZZZ-ZZZZ,ZZ-ZZZZ,,9.99,ZZZ-ZZZZZ,ZZZ-ZZZZZ,""" \
+            """ZZZ-ZZZZ,ZZZ-ZZZZ,ZZZ-ZZZZ,ZZZ-ZZZZ,ZZZ-ZZZZ,ZZZ-ZZZZ,9""" \
+            """99,ZZZ-ZZZZ,,ZZ-ZZZZ,,,,,ZZZZ,ZZZ-ZZZZZ,ZZZ-ZZZZ,,,9,9,""" \
+            """9,9,99,99,999,999,ZZZZZ,ZZZ-ZZZZZ,ZZZ-ZZZZ,9,ZZ-ZZZZ,9.""" \
+            """99,ZZ-ZZZZ,ZZ-ZZZZ,,,,ZZZZ,,,ZZ,ZZ,,,,,,,,,,,,,9,,,999.""" \
+            """99,999.99,,,ZZZZZ,,,Z9,,,,,,,ZZZ,ZZZ,,,,,,,,,,,ZZZZZ,ZZ""" \
+            """ZZZ,ZZZ-ZZZZZZ,ZZZ-ZZZZZZ,ZZ-ZZZZ,ZZ-ZZZZ,ZZ-ZZZZ,ZZ-ZZ""" \
+            """ZZ,,,999999,999999,ZZZ,ZZZ,,,ZZZ,ZZZ,999.99,999.99,,,,Z""" \
+            """ZZ-ZZZ,ZZZ-ZZZ,-9.99,-9.99,9,9,,99,,9.99,9.99,9,9,9.99,""" \
+            """9.99,,,,9.99,9.99,,99,,99,9.99,9.99,,,ZZZ,ZZZ,,999.99,,""" \
+            """999.99,ZZZ,ZZZ-ZZZZ,ZZZ-ZZZZ,,,ZZZZZ,ZZZZZ,ZZZ,ZZZ,9,9,""" \
+            """,,,,,ZZZ-ZZZZ,ZZZ999Z,,,999.99,,999.99,ZZZ-ZZZZ,,,9.999""" \
+            """,9.999,9.999,9.999,-9.999,-9.999,-9.999,-9.999,9.999,9.""" \
+            """999,9.999,9.999,9.999,9.999,9.999,9.999,99999,ZZZ-ZZZZ,""" \
+            """,9.99,ZZZ,,,,,,,,ZZZ,,,,,9,,,,9,,,,,,,,,,ZZZ-ZZZZ,ZZZ-Z""" \
+            """ZZZ,,ZZZZZ,ZZZZZ,ZZZZZ,ZZZZZ,,,9.99,,ZZ-ZZZZ,ZZ-ZZZZ,ZZ""" \
+            """,999,,,,ZZ-ZZZZ,ZZZ,ZZZ,ZZZ-ZZZZ,ZZZ-ZZZZ,,,99.99,99.99""" \
+            """,,,9.99,9.99,9.99,9.99,ZZZ-ZZZZ,,,ZZZ-ZZZZZ,,,,,-9.99,-""" \
+            """9.99,-9.99,-9.99,,,,,,,,,ZZZ-ZZZZ,,9,9.99,9.99,99ZZ,,-9""" \
+            """.99,-9.99,ZZZ-ZZZZ,,,,,,,ZZZ-ZZZZ,9.99,9.99,9999,,,,,,,""" \
+            """,,,-9.9,Z/Z-ZZZZ,999.99,9.99,,999.99,ZZ-ZZZZ,ZZ-ZZZZ,9.""" \
+            """99,9.99,9.99,9.99,9.99,9.99,,ZZZ-ZZZZZ,ZZZ-ZZZZZ,ZZZ-ZZ""" \
+            """ZZZ,ZZZ-ZZZZZ,ZZZ-ZZZZZ,ZZZ,ZZZ,ZZZ,ZZZ,9.99,,,-9.99,ZZ""" \
+            """-ZZZZ,-999.99,,-9999,,999.99,,,,999.99,99.99,,,ZZ-ZZZZZ""" \
+            """ZZZ,ZZ-ZZZZ-ZZZZZZZ,,,,ZZ-ZZ-ZZZZZZZZ,ZZZZZZZZ,ZZZ-ZZZZ""" \
+            """,9999,999.99,ZZZ-ZZZZ,-9.99,-9.99,ZZZ-ZZZZ,99:99:99,,99""" \
+            """,99,,9.99,,-99.99,,,,,,9.99,ZZZ-ZZZZ,-9.99,-9.99,9.99,9""" \
+            """.99,,ZZZ,,,,,,,ZZZ,ZZZ,,,,,"""
+
+        # Set the number of lines so that a call to `parser_trim_buffers`
+        # is triggered: after a couple of full chunks are consumed a
+        # relatively small 'residual' chunk would cause reallocation
+        # within the parser.
+        chunksize, n_lines = 128, 2 * 128 + 15
+        csv_data = "\n".join([record_] * n_lines) + "\n"
+
+        # We will use StringIO to load the CSV from this text buffer.
+        # pd.read_csv() will iterate over the file in chunks and will
+        # finally read a residual chunk of really small size.
+
+        # Generate the expected output: manually create the dataframe
+        # by splitting by comma and repeating the `n_lines` times.
+        row = tuple(val_ if val_ else float("nan")
+                    for val_ in record_.split(","))
+        expected = pd.DataFrame([row for _ in range(n_lines)],
+                                dtype=object, columns=None, index=None)
+
+        # Iterate over the CSV file in chunks of `chunksize` lines
+        chunks_ = self.read_csv(StringIO(csv_data), header=None,
+                                dtype=object, chunksize=chunksize)
+        result = pd.concat(chunks_, axis=0, ignore_index=True)
+
+        # Check for data corruption if there was no segfault
+        tm.assert_frame_equal(result, expected)
diff --git a/pandas/src/parser/tokenizer.c b/pandas/src/parser/tokenizer.c
index 6091c79e2b4fc..ac909f2c8bfdb 100644
--- a/pandas/src/parser/tokenizer.c
+++ b/pandas/src/parser/tokenizer.c
@@ -1221,20 +1221,7 @@ int parser_trim_buffers(parser_t *self) {
     size_t new_cap;
     void *newptr;
 
-    /* trim stream */
-    new_cap = _next_pow2(self->stream_len) + 1;
-    TRACE(("parser_trim_buffers: new_cap = %zu, stream_cap = %zu, lines_cap = %zu\n",
-           new_cap, self->stream_cap, self->lines_cap));
-    if (new_cap < self->stream_cap) {
-        TRACE(("parser_trim_buffers: new_cap < self->stream_cap, calling safe_realloc\n"));
-        newptr = safe_realloc((void*) self->stream, new_cap);
-        if (newptr == NULL) {
-            return PARSER_OUT_OF_MEMORY;
-        } else {
-            self->stream = newptr;
-            self->stream_cap = new_cap;
-        }
-    }
+    int i;
 
     /* trim words, word_starts */
     new_cap = _next_pow2(self->words_len) + 1;
@@ -1255,6 +1242,35 @@ int parser_trim_buffers(parser_t *self) {
         }
     }
 
+    /* trim stream */
+    new_cap = _next_pow2(self->stream_len) + 1;
+    TRACE(("parser_trim_buffers: new_cap = %zu, stream_cap = %zu, lines_cap = %zu\n",
+           new_cap, self->stream_cap, self->lines_cap));
+    if (new_cap < self->stream_cap) {
+        TRACE(("parser_trim_buffers: new_cap < self->stream_cap, calling safe_realloc\n"));
+        newptr = safe_realloc((void*) self->stream, new_cap);
+        if (newptr == NULL) {
+            return PARSER_OUT_OF_MEMORY;
+        } else {
+            // Update the pointers in the self->words array (char **) if `safe_realloc`
+            //  moved the `self->stream` buffer. This block mirrors a similar block in
+            //  `make_stream_space`.
+            if (self->stream != newptr) {
+                /* TRACE(("Moving word pointers\n")) */
+                self->pword_start = newptr + self->word_start;
+
+                for (i = 0; i < self->words_len; ++i)
+                {
+                    self->words[i] = newptr + self->word_starts[i];
+                }
+            }
+
+            self->stream = newptr;
+            self->stream_cap = new_cap;
+
+        }
+    }
+
     /* trim line_start, line_fields */
     new_cap = _next_pow2(self->lines) + 1;
     if (new_cap < self->lines_cap) {