diff --git a/.travis.yml b/.travis.yml
index 4e46fb7ad85ca..abca2fe9c2c7e 100644
--- a/.travis.yml
+++ b/.travis.yml
@@ -57,13 +57,6 @@ matrix:
       - FULL_DEPS=true
       - CLIPBOARD=xsel
       - BUILD_TYPE=conda
-    - python: 3.3
-      env:
-      - JOB_NAME: "33_nslow"
-      - NOSE_ARGS="not slow and not disabled"
-      - FULL_DEPS=true
-      - CLIPBOARD=xsel
-      - BUILD_TYPE=conda
     - python: 2.7
       env:
       - JOB_NAME: "27_slow"
@@ -104,13 +97,6 @@ matrix:
       - BUILD_TYPE=pydata
       - PANDAS_TESTING_MODE="deprecate"
     allow_failures:
-      - python: 3.3
-        env:
-        - JOB_NAME: "33_nslow"
-        - NOSE_ARGS="not slow and not disabled"
-        - FULL_DEPS=true
-        - CLIPBOARD=xsel
-        - BUILD_TYPE=conda
       - python: 2.7
         env:
         - JOB_NAME: "27_slow"
diff --git a/ci/requirements-3.3.build b/ci/requirements-3.3.build
deleted file mode 100644
index ada6686f599ca..0000000000000
--- a/ci/requirements-3.3.build
+++ /dev/null
@@ -1,4 +0,0 @@
-python-dateutil
-pytz=2013b
-numpy=1.7.1
-cython=0.19.1
diff --git a/ci/requirements-3.3.pip b/ci/requirements-3.3.pip
deleted file mode 100644
index 7e172dc039087..0000000000000
--- a/ci/requirements-3.3.pip
+++ /dev/null
@@ -1,2 +0,0 @@
-blosc
-openpyxl
diff --git a/ci/requirements-3.3.run b/ci/requirements-3.3.run
deleted file mode 100644
index 2379ab42391db..0000000000000
--- a/ci/requirements-3.3.run
+++ /dev/null
@@ -1,17 +0,0 @@
-python-dateutil
-pytz=2013b
-numpy=1.7.1
-xlsxwriter=0.4.6
-xlrd=0.9.2
-xlwt
-html5lib=1.0b2
-numexpr
-pytables
-bottleneck=0.8.0
-matplotlib
-patsy
-lxml=3.2.1
-scipy
-beautiful-soup=4.2.1
-statsmodels
-jinja2=2.8
diff --git a/doc/source/install.rst b/doc/source/install.rst
index fcf497c0146c2..b099186f208ae 100644
--- a/doc/source/install.rst
+++ b/doc/source/install.rst
@@ -18,7 +18,7 @@ Instructions for installing from source,
 Python version support
 ----------------------
 
-Officially Python 2.6, 2.7, 3.3, 3.4, and 3.5
+Officially Python 2.6, 2.7, 3.4, and 3.5
 
 Installing pandas
 -----------------
diff --git a/doc/source/whatsnew/v0.18.0.txt b/doc/source/whatsnew/v0.18.0.txt
index 00217eb44e605..65843d4c62a2c 100644
--- a/doc/source/whatsnew/v0.18.0.txt
+++ b/doc/source/whatsnew/v0.18.0.txt
@@ -7,6 +7,10 @@ This is a major release from 0.17.1 and includes a small number of API changes,
 enhancements, and performance improvements along with a large number of bug fixes. We recommend that all
 users upgrade to this version.
 
+.. warning::
+
+   pandas >= 0.18.0 will no longer support compatibility with Python version 3.3 (:issue:`11273`)
+
 Highlights include:
 
 Check the :ref:`API Changes <whatsnew_0180.api>` and :ref:`deprecations <whatsnew_0180.deprecations>` before updating.
diff --git a/setup.py b/setup.py
index 4bb40feb55655..e52c19167c65f 100755
--- a/setup.py
+++ b/setup.py
@@ -180,7 +180,6 @@ def build_extensions(self):
     'Programming Language :: Python :: 3',
     'Programming Language :: Python :: 2.6',
     'Programming Language :: Python :: 2.7',
-    'Programming Language :: Python :: 3.3',
     'Programming Language :: Python :: 3.4',
     'Programming Language :: Python :: 3.5',
     'Programming Language :: Cython',