diff --git a/doc/source/whatsnew/v0.17.0.txt b/doc/source/whatsnew/v0.17.0.txt
index 09a39a6d9b2f5..cd41c4fc82146 100644
--- a/doc/source/whatsnew/v0.17.0.txt
+++ b/doc/source/whatsnew/v0.17.0.txt
@@ -120,7 +120,8 @@ Bug Fixes
 
 - Bug in ``DataFrame.interpolate`` with ``axis=1`` and ``inplace=True`` (:issue:`10395`)
 
-
+- Bug in ``io.sql.get_schema`` when specifying multiple columns as primary
+  key (:issue:`10385`).
 
 
 - Bug in ``test_categorical`` on big-endian builds (:issue:`10425`)
diff --git a/pandas/io/sql.py b/pandas/io/sql.py
index b4e8c7de2b4e1..8d8768c08fe02 100644
--- a/pandas/io/sql.py
+++ b/pandas/io/sql.py
@@ -834,7 +834,11 @@ def _create_table_setup(self):
                    for name, typ, is_index in column_names_and_types]
 
         if self.keys is not None:
-            pkc = PrimaryKeyConstraint(self.keys, name=self.name + '_pk')
+            if not com.is_list_like(self.keys):
+                keys = [self.keys]
+            else:
+                keys = self.keys
+            pkc = PrimaryKeyConstraint(*keys, name=self.name + '_pk')
             columns.append(pkc)
 
         schema = self.schema or self.pd_sql.meta.schema
@@ -899,8 +903,8 @@ def _harmonize_columns(self, parse_dates=None):
 
     def _get_notnull_col_dtype(self, col):
         """
-        Infer datatype of the Series col.  In case the dtype of col is 'object' 
-        and it contains NA values, this infers the datatype of the not-NA 
+        Infer datatype of the Series col.  In case the dtype of col is 'object'
+        and it contains NA values, this infers the datatype of the not-NA
         values.  Needed for inserting typed data containing NULLs, GH8778.
         """
         col_for_inference = col
@@ -1272,7 +1276,7 @@ def _get_unicode_name(name):
     return uname
 
 def _get_valid_mysql_name(name):
-    # Filter for unquoted identifiers 
+    # Filter for unquoted identifiers
     # See http://dev.mysql.com/doc/refman/5.0/en/identifiers.html
     uname = _get_unicode_name(name)
     if not len(uname):
@@ -1293,7 +1297,7 @@ def _get_valid_sqlite_name(name):
     # Ensure the string does not include any NUL characters.
     # Replace all " with "".
     # Wrap the entire thing in double quotes.
-    
+
     uname = _get_unicode_name(name)
     if not len(uname):
         raise ValueError("Empty table or column name specified")
@@ -1377,7 +1381,11 @@ def _create_table_setup(self):
                             for cname, ctype, _ in column_names_and_types]
 
         if self.keys is not None and len(self.keys):
-            cnames_br = ",".join([escape(c) for c in self.keys])
+            if not com.is_list_like(self.keys):
+                keys = [self.keys]
+            else:
+                keys = self.keys
+            cnames_br = ", ".join([escape(c) for c in keys])
             create_tbl_stmts.append(
                 "CONSTRAINT {tbl}_pk PRIMARY KEY ({cnames_br})".format(
                 tbl=self.name, cnames_br=cnames_br))
@@ -1391,7 +1399,7 @@ def _create_table_setup(self):
             cnames = "_".join(ix_cols)
             cnames_br = ",".join([escape(c) for c in ix_cols])
             create_stmts.append(
-                "CREATE INDEX " + escape("ix_"+self.name+"_"+cnames) + 
+                "CREATE INDEX " + escape("ix_"+self.name+"_"+cnames) +
                 "ON " + escape(self.name) + " (" + cnames_br + ")")
 
         return create_stmts
@@ -1416,7 +1424,7 @@ def _sql_type_name(self, col):
 
         elif col_type == "complex":
             raise ValueError('Complex datatypes not supported')
-            
+
         if col_type not in _SQL_TYPES:
             col_type = "string"
 
diff --git a/pandas/io/tests/test_sql.py b/pandas/io/tests/test_sql.py
index 33ea63ba41f1f..d8bc3c61f68f0 100644
--- a/pandas/io/tests/test_sql.py
+++ b/pandas/io/tests/test_sql.py
@@ -703,6 +703,19 @@ def test_get_schema_dtypes(self):
         self.assertTrue('CREATE' in create_sql)
         self.assertTrue('INTEGER' in create_sql)
 
+    def test_get_schema_keys(self):
+        frame = DataFrame({'Col1':[1.1,1.2], 'Col2':[2.1,2.2]})
+        create_sql = sql.get_schema(frame, 'test', 'sqlite',
+                                    con=self.conn, keys='Col1')
+        constraint_sentence = 'CONSTRAINT test_pk PRIMARY KEY ("Col1")'
+        self.assertTrue(constraint_sentence in create_sql)
+
+        # multiple columns as key (GH10385)
+        create_sql = sql.get_schema(self.test_frame1, 'test', 'sqlite',
+                                    con=self.conn, keys=['A', 'B'])
+        constraint_sentence = 'CONSTRAINT test_pk PRIMARY KEY ("A", "B")'
+        self.assertTrue(constraint_sentence in create_sql)
+
     def test_chunksize_read(self):
         df = DataFrame(np.random.randn(22, 5), columns=list('abcde'))
         df.to_sql('test_chunksize', self.conn, index=False)
@@ -1851,7 +1864,7 @@ def test_illegal_names(self):
             df2 = DataFrame([[1, 2], [3, 4]], columns=['a', ok_name])
             c_tbl = 'test_ok_col_name%d'%ndx
             df2.to_sql(c_tbl, self.conn, flavor=self.flavor, index=False,
-                      if_exists='replace')   
+                      if_exists='replace')
             self.conn.cursor().execute("DROP TABLE `%s`" % c_tbl)
             self.conn.commit()
 
@@ -1962,7 +1975,7 @@ def test_schema(self):
         frame = tm.makeTimeDataFrame()
         create_sql = sql.get_schema(frame, 'test', 'sqlite', keys=['A', 'B'],)
         lines = create_sql.splitlines()
-        self.assertTrue('PRIMARY KEY ("A","B")' in create_sql)
+        self.assertTrue('PRIMARY KEY ("A", "B")' in create_sql)
         cur = self.db.cursor()
         cur.execute(create_sql)
 
@@ -2277,7 +2290,7 @@ def test_schema(self):
         drop_sql = "DROP TABLE IF EXISTS test"
         create_sql = sql.get_schema(frame, 'test', 'mysql', keys=['A', 'B'],)
         lines = create_sql.splitlines()
-        self.assertTrue('PRIMARY KEY (`A`,`B`)' in create_sql)
+        self.assertTrue('PRIMARY KEY (`A`, `B`)' in create_sql)
         cur = self.db.cursor()
         cur.execute(drop_sql)
         cur.execute(create_sql)