diff --git a/pandas-stubs/core/series.pyi b/pandas-stubs/core/series.pyi
index d38b54dae..6b1cf01b9 100644
--- a/pandas-stubs/core/series.pyi
+++ b/pandas-stubs/core/series.pyi
@@ -198,6 +198,7 @@ class _LocIndexerSeries(_LocIndexer, Generic[S1]):
             | list[str]
             | slice
             | _IndexSliceTuple
+            | Sequence[_IndexSliceTuple]
             | Callable
         ),
         # _IndexSliceTuple is when having a tuple that includes a slice.  Could just
diff --git a/tests/test_series.py b/tests/test_series.py
index 8bbe0f8d7..ea6110ec5 100644
--- a/tests/test_series.py
+++ b/tests/test_series.py
@@ -176,6 +176,20 @@ def test_multiindex_loc() -> None:
     check(assert_type(s.loc[1, "a"], int), np.int_)
 
 
+def test_multiindex_loc_str_tuple() -> None:
+    s = pd.Series(
+        [1, 2, 3, 4, 5, 6],
+        index=pd.MultiIndex.from_product([["A", "B"], ["c", "d", "e"]]),
+        dtype=int,
+    )
+    check(assert_type(s.loc[("A", "c")], int), np.int_)
+    check(
+        assert_type(s.loc[[("A", "c"), ("B", "d")]], "pd.Series[int]"),
+        pd.Series,
+        np.int_,
+    )
+
+
 def test_types_boolean_indexing() -> None:
     s = pd.Series([0, 1, 2])
     s[s > 1]