diff --git a/pandas-stubs/core/frame.pyi b/pandas-stubs/core/frame.pyi
index d5f138e11..f8913c5cc 100644
--- a/pandas-stubs/core/frame.pyi
+++ b/pandas-stubs/core/frame.pyi
@@ -161,7 +161,12 @@ class _LocIndexerFrame(_LocIndexer):
         | Callable[[DataFrame], IndexType | MaskType | list[HashableT]]
         | list[HashableT]
         | tuple[
-            IndexType | MaskType | list[HashableT] | Hashable,
+            IndexType
+            | MaskType
+            | list[HashableT]
+            | slice
+            | _IndexSliceTuple
+            | Callable,
             list[HashableT] | slice | Series[bool] | Callable,
         ],
     ) -> DataFrame: ...
@@ -188,6 +193,8 @@ class _LocIndexerFrame(_LocIndexer):
         | None,
     ) -> Series: ...
     @overload
+    def __getitem__(self, idx: tuple[Scalar, slice]) -> Series | DataFrame: ...
+    @overload
     def __setitem__(
         self,
         idx: MaskType | StrLike | _IndexSliceTuple | list[ScalarT],
diff --git a/tests/test_frame.py b/tests/test_frame.py
index 064f208bf..c6e57f58a 100644
--- a/tests/test_frame.py
+++ b/tests/test_frame.py
@@ -2172,7 +2172,7 @@ def test_loc_slice() -> None:
         {"x": [1, 2, 3, 4]},
         index=pd.MultiIndex.from_product([[1, 2], ["a", "b"]], names=["num", "let"]),
     )
-    check(assert_type(df1.loc[1, :], pd.DataFrame), pd.DataFrame)
+    check(assert_type(df1.loc[1, :], Union[pd.Series, pd.DataFrame]), pd.DataFrame)
 
 
 def test_where() -> None:
@@ -2521,3 +2521,9 @@ def test_align() -> None:
     aligned_df0, aligned_df1 = df0.align(df1)
     check(assert_type(aligned_df0, pd.DataFrame), pd.DataFrame)
     check(assert_type(aligned_df1, pd.DataFrame), pd.DataFrame)
+
+
+def test_loc_returns_series() -> None:
+    df1 = pd.DataFrame({"x": [1, 2, 3, 4]}, index=[10, 20, 30, 40])
+    df2 = df1.loc[10, :]
+    check(assert_type(df2, Union[pd.Series, pd.DataFrame]), pd.Series)