diff --git a/connection.go b/connection.go
index 265fd4e47..565a5480a 100644
--- a/connection.go
+++ b/connection.go
@@ -213,6 +213,9 @@ func (mc *mysqlConn) interpolateParams(query string, args []driver.Value) (strin
 		switch v := arg.(type) {
 		case int64:
 			buf = strconv.AppendInt(buf, v, 10)
+		case uint64:
+			// Handle uint64 explicitly because our custom ConvertValue emits unsigned values
+			buf = strconv.AppendUint(buf, v, 10)
 		case float64:
 			buf = strconv.AppendFloat(buf, v, 'g', -1, 64)
 		case bool:
diff --git a/connection_test.go b/connection_test.go
index 8e78f36c6..19c17ff8b 100644
--- a/connection_test.go
+++ b/connection_test.go
@@ -69,6 +69,24 @@ func TestInterpolateParamsPlaceholderInString(t *testing.T) {
 	}
 }
 
+func TestInterpolateParamsUint64(t *testing.T) {
+	mc := &mysqlConn{
+		buf:              newBuffer(nil),
+		maxAllowedPacket: maxPacketSize,
+		cfg: &Config{
+			InterpolateParams: true,
+		},
+	}
+
+	q, err := mc.interpolateParams("SELECT ?", []driver.Value{uint64(42)})
+	if err != nil {
+		t.Errorf("Expected err=nil, got err=%#v, q=%#v", err, q)
+	}
+	if q != "SELECT 42" {
+		t.Errorf("Expected uint64 interpolation to work, got q=%#v", q)
+	}
+}
+
 func TestCheckNamedValue(t *testing.T) {
 	value := driver.NamedValue{Value: ^uint64(0)}
 	x := &mysqlConn{}