diff --git a/git/diff.py b/git/diff.py
index c315a9a95..48b0e0d62 100644
--- a/git/diff.py
+++ b/git/diff.py
@@ -570,7 +570,10 @@ def _index_from_patch_format(cls, repo: "Repo", proc: Union["Popen", "Git.AutoIn
     def _handle_diff_line(lines_bytes: bytes, repo: "Repo", index: DiffIndex) -> None:
         lines = lines_bytes.decode(defenc)
 
-        for line in lines.split(":")[1:]:
+        # Discard everything before the first colon, and the colon itself.
+        _, _, lines = lines.partition(":")
+
+        for line in lines.split("\x00:"):
             meta, _, path = line.partition("\x00")
             path = path.rstrip("\x00")
             a_blob_id: Optional[str]
diff --git a/test/test_diff.py b/test/test_diff.py
index 3e1c5ddc8..dcf10018b 100644
--- a/test/test_diff.py
+++ b/test/test_diff.py
@@ -236,7 +236,6 @@ def test_diff_index_raw_format(self):
             res[0].b_path,
         )
 
-    @unittest.skip("This currently fails and would need someone to improve diff parsing")
     def test_diff_file_with_colon(self):
         output = fixture("diff_file_with_colon")
         res = []