diff --git a/src/sagemaker/jumpstart/artifacts/model_packages.py b/src/sagemaker/jumpstart/artifacts/model_packages.py
index 0fbf1d74b3..da3513cc1d 100644
--- a/src/sagemaker/jumpstart/artifacts/model_packages.py
+++ b/src/sagemaker/jumpstart/artifacts/model_packages.py
@@ -72,6 +72,13 @@ def _retrieve_model_package_arn(
 
         regional_arn = model_specs.hosting_model_package_arns.get(region)
 
+        if regional_arn is None:
+            raise ValueError(
+                f"Model package arn for '{model_id}' not supported in {region}. "
+                "Please try one of the following regions: "
+                f"{', '.join(model_specs.hosting_model_package_arns.keys())}."
+            )
+
         return regional_arn
 
     raise NotImplementedError(f"Model Package ARN not supported for scope: '{scope}'")
@@ -130,6 +137,13 @@ def _retrieve_model_package_model_artifact_s3_uri(
 
         model_s3_uri = model_specs.training_model_package_artifact_uris.get(region)
 
+        if model_s3_uri is None:
+            raise ValueError(
+                f"Model package artifact s3 uri for '{model_id}' not supported in {region}. "
+                "Please try one of the following regions: "
+                f"{', '.join(model_specs.training_model_package_artifact_uris.keys())}."
+            )
+
         return model_s3_uri
 
     raise NotImplementedError(f"Model Package Artifact URI not supported for scope: '{scope}'")
diff --git a/tests/unit/sagemaker/jumpstart/estimator/test_estimator.py b/tests/unit/sagemaker/jumpstart/estimator/test_estimator.py
index 198839475b..60420be9c2 100644
--- a/tests/unit/sagemaker/jumpstart/estimator/test_estimator.py
+++ b/tests/unit/sagemaker/jumpstart/estimator/test_estimator.py
@@ -353,6 +353,49 @@ def test_gated_model_s3_uri(
             use_compiled_model=False,
         )
 
+    @mock.patch("sagemaker.utils.sagemaker_timestamp")
+    @mock.patch("sagemaker.jumpstart.estimator.is_valid_model_id")
+    @mock.patch("sagemaker.jumpstart.factory.model.Session")
+    @mock.patch("sagemaker.jumpstart.factory.estimator.Session")
+    @mock.patch("sagemaker.jumpstart.accessors.JumpStartModelsAccessor.get_model_specs")
+    @mock.patch("sagemaker.jumpstart.estimator.Estimator.__init__")
+    @mock.patch("sagemaker.jumpstart.estimator.Estimator.fit")
+    @mock.patch("sagemaker.jumpstart.estimator.Estimator.deploy")
+    @mock.patch("sagemaker.jumpstart.factory.estimator.JUMPSTART_DEFAULT_REGION_NAME", region)
+    @mock.patch("sagemaker.jumpstart.factory.model.JUMPSTART_DEFAULT_REGION_NAME", region)
+    def test_jumpstart_model_package_artifact_s3_uri_unsupported_region(
+        self,
+        mock_estimator_deploy: mock.Mock,
+        mock_estimator_fit: mock.Mock,
+        mock_estimator_init: mock.Mock,
+        mock_get_model_specs: mock.Mock,
+        mock_session_estimator: mock.Mock,
+        mock_session_model: mock.Mock,
+        mock_is_valid_model_id: mock.Mock,
+        mock_timestamp: mock.Mock,
+    ):
+        mock_estimator_deploy.return_value = default_predictor
+
+        mock_timestamp.return_value = "8675309"
+
+        mock_is_valid_model_id.return_value = True
+
+        model_id, _ = "js-gated-artifact-trainable-model", "*"
+
+        mock_get_model_specs.side_effect = get_special_model_spec
+
+        mock_session_estimator.return_value = sagemaker_session
+        mock_session_model.return_value = sagemaker_session
+
+        with pytest.raises(ValueError) as e:
+            JumpStartEstimator(model_id=model_id, region="eu-north-1")
+
+        assert (
+            str(e.value) == "Model package artifact s3 uri for 'js-gated-artifact-trainable-model' "
+            "not supported in eu-north-1. Please try one of the following regions: "
+            "us-west-2, us-east-1, eu-west-1, ap-southeast-1."
+        )
+
     @mock.patch("sagemaker.jumpstart.estimator.is_valid_model_id")
     @mock.patch("sagemaker.jumpstart.accessors.JumpStartModelsAccessor.get_model_specs")
     @mock.patch("sagemaker.jumpstart.estimator.Estimator.__init__")
diff --git a/tests/unit/sagemaker/jumpstart/model/test_model.py b/tests/unit/sagemaker/jumpstart/model/test_model.py
index fb7698741e..5194a18e16 100644
--- a/tests/unit/sagemaker/jumpstart/model/test_model.py
+++ b/tests/unit/sagemaker/jumpstart/model/test_model.py
@@ -646,6 +646,32 @@ def test_jumpstart_model_package_arn_override(
             },
         )
 
+    @mock.patch("sagemaker.jumpstart.model.is_valid_model_id")
+    @mock.patch("sagemaker.jumpstart.factory.model.Session")
+    @mock.patch("sagemaker.jumpstart.accessors.JumpStartModelsAccessor.get_model_specs")
+    @mock.patch("sagemaker.jumpstart.factory.model.JUMPSTART_DEFAULT_REGION_NAME", region)
+    def test_jumpstart_model_package_arn_unsupported_region(
+        self,
+        mock_get_model_specs: mock.Mock,
+        mock_session: mock.Mock,
+        mock_is_valid_model_id: mock.Mock,
+    ):
+
+        mock_is_valid_model_id.return_value = True
+
+        model_id, _ = "js-model-package-arn", "*"
+
+        mock_get_model_specs.side_effect = get_special_model_spec
+
+        mock_session.return_value = MagicMock(sagemaker_config={})
+
+        with pytest.raises(ValueError) as e:
+            JumpStartModel(model_id=model_id, region="us-east-2")
+        assert (
+            str(e.value) == "Model package arn for 'js-model-package-arn' not supported in "
+            "us-east-2. Please try one of the following regions: us-west-2, us-east-1."
+        )
+
 
 def test_jumpstart_model_requires_model_id():
     with pytest.raises(ValueError):