diff --git a/src/sagemaker/image_uri_config/image-classification-neo.json b/src/sagemaker/image_uri_config/image-classification-neo.json
index b668744f3b..371bd445a9 100644
--- a/src/sagemaker/image_uri_config/image-classification-neo.json
+++ b/src/sagemaker/image_uri_config/image-classification-neo.json
@@ -25,6 +25,8 @@
                 "us-east-1": "785573368785",
                 "us-east-2": "007439368137",
                 "us-gov-west-1": "263933020539",
+                "us-iso-east-1": "167761179201",
+                "us-isob-east-1": "406031935815",
                 "us-west-1": "710691900526",
                 "us-west-2": "301217895009"
             },
diff --git a/src/sagemaker/image_uri_config/inferentia-mxnet.json b/src/sagemaker/image_uri_config/inferentia-mxnet.json
index cc8d17cf66..d53c21f7e2 100644
--- a/src/sagemaker/image_uri_config/inferentia-mxnet.json
+++ b/src/sagemaker/image_uri_config/inferentia-mxnet.json
@@ -27,6 +27,8 @@
                 "us-east-1": "785573368785",
                 "us-east-2": "007439368137",
                 "us-gov-west-1": "263933020539",
+                "us-iso-east-1": "167761179201",
+                "us-isob-east-1": "406031935815",
                 "us-west-1": "710691900526",
                 "us-west-2": "301217895009"                
             },
@@ -57,6 +59,8 @@
                 "us-east-1": "785573368785",
                 "us-east-2": "007439368137",
                 "us-gov-west-1": "263933020539",
+                "us-iso-east-1": "167761179201",
+                "us-isob-east-1": "406031935815",
                 "us-west-1": "710691900526",
                 "us-west-2": "301217895009"
             },
diff --git a/src/sagemaker/image_uri_config/inferentia-pytorch.json b/src/sagemaker/image_uri_config/inferentia-pytorch.json
index 6259c7becd..b3d8c80c21 100644
--- a/src/sagemaker/image_uri_config/inferentia-pytorch.json
+++ b/src/sagemaker/image_uri_config/inferentia-pytorch.json
@@ -27,6 +27,8 @@
                 "us-east-1": "785573368785",
                 "us-east-2": "007439368137",
                 "us-gov-west-1": "263933020539",
+                "us-iso-east-1": "167761179201",
+                "us-isob-east-1": "406031935815",
                 "us-west-1": "710691900526",
                 "us-west-2": "301217895009"
             },
@@ -57,6 +59,8 @@
                 "us-east-1": "785573368785",
                 "us-east-2": "007439368137",
                 "us-gov-west-1": "263933020539",
+                "us-iso-east-1": "167761179201",
+                "us-isob-east-1": "406031935815",
                 "us-west-1": "710691900526",
                 "us-west-2": "301217895009"
             },
@@ -87,6 +91,8 @@
                 "us-east-1": "785573368785",
                 "us-east-2": "007439368137",
                 "us-gov-west-1": "263933020539",
+                "us-iso-east-1": "167761179201",
+                "us-isob-east-1": "406031935815",
                 "us-west-1": "710691900526",
                 "us-west-2": "301217895009"
             },
diff --git a/src/sagemaker/image_uri_config/inferentia-tensorflow.json b/src/sagemaker/image_uri_config/inferentia-tensorflow.json
index ae1aa1fd11..ce1d2603b6 100644
--- a/src/sagemaker/image_uri_config/inferentia-tensorflow.json
+++ b/src/sagemaker/image_uri_config/inferentia-tensorflow.json
@@ -27,6 +27,8 @@
                 "us-east-1": "785573368785",
                 "us-east-2": "007439368137",
                 "us-gov-west-1": "263933020539",
+                "us-iso-east-1": "167761179201",
+                "us-isob-east-1": "406031935815",
                 "us-west-1": "710691900526",
                 "us-west-2": "301217895009"                
             },
@@ -57,6 +59,8 @@
                 "us-east-1": "785573368785",
                 "us-east-2": "007439368137",
                 "us-gov-west-1": "263933020539",
+                "us-iso-east-1": "167761179201",
+                "us-isob-east-1": "406031935815",
                 "us-west-1": "710691900526",
                 "us-west-2": "301217895009"
             },
diff --git a/src/sagemaker/image_uri_config/neo-mxnet.json b/src/sagemaker/image_uri_config/neo-mxnet.json
index 66f2453af5..268abde298 100644
--- a/src/sagemaker/image_uri_config/neo-mxnet.json
+++ b/src/sagemaker/image_uri_config/neo-mxnet.json
@@ -41,6 +41,8 @@
                 "us-east-1": "785573368785",
                 "us-east-2": "007439368137",
                 "us-gov-west-1": "263933020539",
+                "us-iso-east-1": "167761179201",
+                "us-isob-east-1": "406031935815",
                 "us-west-1": "710691900526",
                 "us-west-2": "301217895009"
             },
diff --git a/src/sagemaker/image_uri_config/neo-pytorch.json b/src/sagemaker/image_uri_config/neo-pytorch.json
index a0fd287132..bd15a6450e 100644
--- a/src/sagemaker/image_uri_config/neo-pytorch.json
+++ b/src/sagemaker/image_uri_config/neo-pytorch.json
@@ -39,6 +39,8 @@
                 "us-east-1": "785573368785",
                 "us-east-2": "007439368137",
                 "us-gov-west-1": "263933020539",
+                "us-iso-east-1": "167761179201",
+                "us-isob-east-1": "406031935815",
                 "us-west-1": "710691900526",
                 "us-west-2": "301217895009"
             },
@@ -69,6 +71,8 @@
                 "us-east-1": "785573368785",
                 "us-east-2": "007439368137",
                 "us-gov-west-1": "263933020539",
+                "us-iso-east-1": "167761179201",
+                "us-isob-east-1": "406031935815",
                 "us-west-1": "710691900526",
                 "us-west-2": "301217895009"
             },
@@ -99,6 +103,8 @@
                 "us-east-1": "785573368785",
                 "us-east-2": "007439368137",
                 "us-gov-west-1": "263933020539",
+                "us-iso-east-1": "167761179201",
+                "us-isob-east-1": "406031935815",
                 "us-west-1": "710691900526",
                 "us-west-2": "301217895009"
             },
@@ -129,6 +135,8 @@
                 "us-east-1": "785573368785",
                 "us-east-2": "007439368137",
                 "us-gov-west-1": "263933020539",
+                "us-iso-east-1": "167761179201",
+                "us-isob-east-1": "406031935815",
                 "us-west-1": "710691900526",
                 "us-west-2": "301217895009"
             },
@@ -159,6 +167,8 @@
                 "us-east-1": "785573368785",
                 "us-east-2": "007439368137",
                 "us-gov-west-1": "263933020539",
+                "us-iso-east-1": "167761179201",
+                "us-isob-east-1": "406031935815",
                 "us-west-1": "710691900526",
                 "us-west-2": "301217895009"
             },
diff --git a/src/sagemaker/image_uri_config/neo-tensorflow.json b/src/sagemaker/image_uri_config/neo-tensorflow.json
index e5acd35e51..f7fb0fc5c3 100644
--- a/src/sagemaker/image_uri_config/neo-tensorflow.json
+++ b/src/sagemaker/image_uri_config/neo-tensorflow.json
@@ -47,6 +47,8 @@
                 "us-east-1": "785573368785",
                 "us-east-2": "007439368137",
                 "us-gov-west-1": "263933020539",
+                "us-iso-east-1": "167761179201",
+                "us-isob-east-1": "406031935815",
                 "us-west-1": "710691900526",
                 "us-west-2": "301217895009"
             },
@@ -77,6 +79,8 @@
                 "us-east-1": "785573368785",
                 "us-east-2": "007439368137",
                 "us-gov-west-1": "263933020539",
+                "us-iso-east-1": "167761179201",
+                "us-isob-east-1": "406031935815",
                 "us-west-1": "710691900526",
                 "us-west-2": "301217895009"
             },
diff --git a/src/sagemaker/image_uri_config/xgboost-neo.json b/src/sagemaker/image_uri_config/xgboost-neo.json
index 434c882977..8c44ff381c 100644
--- a/src/sagemaker/image_uri_config/xgboost-neo.json
+++ b/src/sagemaker/image_uri_config/xgboost-neo.json
@@ -25,6 +25,8 @@
                 "us-east-1": "785573368785",
                 "us-east-2": "007439368137",
                 "us-gov-west-1": "263933020539",
+                "us-iso-east-1": "167761179201",
+                "us-isob-east-1": "406031935815",
                 "us-west-1": "710691900526",
                 "us-west-2": "301217895009"
             },
diff --git a/tests/unit/sagemaker/image_uris/expected_uris.py b/tests/unit/sagemaker/image_uris/expected_uris.py
index 0574536754..a38ca2c8bf 100644
--- a/tests/unit/sagemaker/image_uris/expected_uris.py
+++ b/tests/unit/sagemaker/image_uris/expected_uris.py
@@ -16,6 +16,7 @@
     "cn-north-1": "amazonaws.com.cn",
     "cn-northwest-1": "amazonaws.com.cn",
     "us-iso-east-1": "c2s.ic.gov",
+    "us-isob-east-1": "sc2s.sgov.gov",
 }
 DOMAIN = "amazonaws.com"
 IMAGE_URI_FORMAT = "{}.dkr.ecr.{}.{}/{}:{}"
diff --git a/tests/unit/sagemaker/image_uris/test_neo.py b/tests/unit/sagemaker/image_uris/test_neo.py
index d630862381..61d758b403 100644
--- a/tests/unit/sagemaker/image_uris/test_neo.py
+++ b/tests/unit/sagemaker/image_uris/test_neo.py
@@ -42,6 +42,8 @@
     "us-east-1": "785573368785",
     "us-east-2": "007439368137",
     "us-gov-west-1": "263933020539",
+    "us-iso-east-1": "167761179201",
+    "us-isob-east-1": "406031935815",
     "us-west-1": "710691900526",
     "us-west-2": "301217895009",
 }