diff --git a/src/sagemaker/estimator.py b/src/sagemaker/estimator.py
index 15763d844b..c4581f5a9f 100644
--- a/src/sagemaker/estimator.py
+++ b/src/sagemaker/estimator.py
@@ -44,6 +44,7 @@
     UploadedCode,
     _region_supports_debugger,
     _region_supports_profiler,
+    _instance_type_supports_profiler,
     get_mp_parameters,
     tar_and_upload_dir,
     validate_source_dir,
@@ -592,7 +593,9 @@ def __init__(
 
         self.max_retry_attempts = max_retry_attempts
 
-        if not _region_supports_profiler(self.sagemaker_session.boto_region_name):
+        if not _region_supports_profiler(
+            self.sagemaker_session.boto_region_name
+        ) or _instance_type_supports_profiler(self.instance_type):
             self.disable_profiler = True
 
         self.profiler_rule_configs = None
diff --git a/src/sagemaker/fw_utils.py b/src/sagemaker/fw_utils.py
index f86304e720..6b9653520e 100644
--- a/src/sagemaker/fw_utils.py
+++ b/src/sagemaker/fw_utils.py
@@ -1065,6 +1065,22 @@ def _region_supports_profiler(region_name):
     return region_name.lower() not in PROFILER_UNSUPPORTED_REGIONS
 
 
+def _instance_type_supports_profiler(instance_type):
+    """Returns bool indicating whether instance_type supports SageMaker Debugger profiling feature.
+
+    Args:
+        instance_type (str): Name of the instance_type to check against.
+
+    Returns:
+        bool: Whether or not the region supports Amazon SageMaker Debugger profiling feature.
+    """
+    if isinstance(instance_type, str):
+        match = re.match(r"^ml[\._]([a-z\d]+)\.?\w*$", instance_type)
+        if match and match[1].startswith("trn"):
+            return True
+    return False
+
+
 def validate_version_or_image_args(framework_version, py_version, image_uri):
     """Checks if version or image arguments are specified.
 
diff --git a/tests/unit/test_fw_utils.py b/tests/unit/test_fw_utils.py
index 1badd1be0c..51b240f156 100644
--- a/tests/unit/test_fw_utils.py
+++ b/tests/unit/test_fw_utils.py
@@ -1040,3 +1040,9 @@ def test_validate_unsupported_distributions_trainium_raises():
             distribution=smdataparallel_enabled,
             instance_type="ml.trn1.32xlarge",
         )
+
+
+def test_instance_type_supports_profiler():
+    assert fw_utils._instance_type_supports_profiler("ml.trn1.xlarge") is True
+    assert fw_utils._instance_type_supports_profiler("ml.m4.xlarge") is False
+    assert fw_utils._instance_type_supports_profiler("local") is False