diff --git a/.changes/next-release/bugfix-AmazonS3-77f8946.json b/.changes/next-release/bugfix-AmazonS3-77f8946.json
new file mode 100644
index 000000000000..fb3f85ea8ba8
--- /dev/null
+++ b/.changes/next-release/bugfix-AmazonS3-77f8946.json
@@ -0,0 +1,6 @@
+{
+    "type": "bugfix",
+    "category": "Amazon S3",
+    "contributor": "",
+    "description": "Add `Expect: 100-continue` header for `UploadPartRequest` so that a upload part request can fail faster if there is a server error."
+}
diff --git a/services/s3/src/main/java/software/amazon/awssdk/services/s3/internal/handlers/PutObjectInterceptor.java b/services/s3/src/main/java/software/amazon/awssdk/services/s3/internal/handlers/StreamingRequestInterceptor.java
similarity index 85%
rename from services/s3/src/main/java/software/amazon/awssdk/services/s3/internal/handlers/PutObjectInterceptor.java
rename to services/s3/src/main/java/software/amazon/awssdk/services/s3/internal/handlers/StreamingRequestInterceptor.java
index 92859b96dea9..82a47cee6f3b 100644
--- a/services/s3/src/main/java/software/amazon/awssdk/services/s3/internal/handlers/PutObjectInterceptor.java
+++ b/services/s3/src/main/java/software/amazon/awssdk/services/s3/internal/handlers/StreamingRequestInterceptor.java
@@ -21,17 +21,18 @@
 import software.amazon.awssdk.core.interceptor.ExecutionInterceptor;
 import software.amazon.awssdk.http.SdkHttpRequest;
 import software.amazon.awssdk.services.s3.model.PutObjectRequest;
+import software.amazon.awssdk.services.s3.model.UploadPartRequest;
 
 /**
  * Interceptor to add an 'Expect: 100-continue' header to the HTTP Request if it represents a PUT Object request.
  */
 @SdkInternalApi
 //TODO: This should be generalized for all streaming requests
-public final class PutObjectInterceptor implements ExecutionInterceptor {
+public final class StreamingRequestInterceptor implements ExecutionInterceptor {
     @Override
     public SdkHttpRequest modifyHttpRequest(Context.ModifyHttpRequest context,
                                             ExecutionAttributes executionAttributes) {
-        if (context.request() instanceof PutObjectRequest) {
+        if (context.request() instanceof PutObjectRequest || context.request() instanceof UploadPartRequest) {
             return context.httpRequest().toBuilder().putHeader("Expect", "100-continue").build();
         }
         return context.httpRequest();
diff --git a/services/s3/src/main/resources/codegen-resources/customization.config b/services/s3/src/main/resources/codegen-resources/customization.config
index 1a1efb76c5f4..71f5a2aef642 100644
--- a/services/s3/src/main/resources/codegen-resources/customization.config
+++ b/services/s3/src/main/resources/codegen-resources/customization.config
@@ -237,7 +237,7 @@
   "asyncClientDecorator": "software.amazon.awssdk.services.s3.internal.client.S3AsyncClientDecorator",
   "useGlobalEndpoint": true,
   "interceptors": [
-    "software.amazon.awssdk.services.s3.internal.handlers.PutObjectInterceptor",
+    "software.amazon.awssdk.services.s3.internal.handlers.StreamingRequestInterceptor",
     "software.amazon.awssdk.services.s3.internal.handlers.CreateBucketInterceptor",
     "software.amazon.awssdk.services.s3.internal.handlers.CreateMultipartUploadRequestInterceptor",
     "software.amazon.awssdk.services.s3.internal.handlers.EnableChunkedEncodingInterceptor",
diff --git a/services/s3/src/test/java/software/amazon/awssdk/services/s3/internal/handlers/PutObjectInterceptorTest.java b/services/s3/src/test/java/software/amazon/awssdk/services/s3/internal/handlers/StreamingRequestInterceptorTest.java
similarity index 74%
rename from services/s3/src/test/java/software/amazon/awssdk/services/s3/internal/handlers/PutObjectInterceptorTest.java
rename to services/s3/src/test/java/software/amazon/awssdk/services/s3/internal/handlers/StreamingRequestInterceptorTest.java
index 08dce580bc95..3a8e9537147f 100644
--- a/services/s3/src/test/java/software/amazon/awssdk/services/s3/internal/handlers/PutObjectInterceptorTest.java
+++ b/services/s3/src/test/java/software/amazon/awssdk/services/s3/internal/handlers/StreamingRequestInterceptorTest.java
@@ -23,9 +23,10 @@
 import software.amazon.awssdk.http.SdkHttpRequest;
 import software.amazon.awssdk.services.s3.model.GetObjectRequest;
 import software.amazon.awssdk.services.s3.model.PutObjectRequest;
+import software.amazon.awssdk.services.s3.model.UploadPartRequest;
 
-public class PutObjectInterceptorTest {
-    private final PutObjectInterceptor interceptor = new PutObjectInterceptor();
+public class StreamingRequestInterceptorTest {
+    private final StreamingRequestInterceptor interceptor = new StreamingRequestInterceptor();
 
     @Test
     public void modifyHttpRequest_setsExpect100Continue_whenSdkRequestIsPutObject() {
@@ -36,6 +37,16 @@ public void modifyHttpRequest_setsExpect100Continue_whenSdkRequestIsPutObject()
         assertThat(modifiedRequest.firstMatchingHeader("Expect")).hasValue("100-continue");
     }
 
+    @Test
+    public void modifyHttpRequest_setsExpect100Continue_whenSdkRequestIsUploadPart() {
+
+        final SdkHttpRequest modifiedRequest =
+            interceptor.modifyHttpRequest(modifyHttpRequestContext(UploadPartRequest.builder().build()),
+                                                                             new ExecutionAttributes());
+
+        assertThat(modifiedRequest.firstMatchingHeader("Expect")).hasValue("100-continue");
+    }
+
     @Test
     public void modifyHttpRequest_doesNotSetExpect_whenSdkRequestIsNotPutObject() {