diff --git a/aws_lambda_powertools/event_handler/api_gateway.py b/aws_lambda_powertools/event_handler/api_gateway.py
index ae02a659359..4fdce465dab 100644
--- a/aws_lambda_powertools/event_handler/api_gateway.py
+++ b/aws_lambda_powertools/event_handler/api_gateway.py
@@ -143,8 +143,8 @@ class Response:
     def __init__(
         self,
         status_code: int,
-        content_type: Optional[str],
-        body: Union[str, bytes, None],
+        content_type: Optional[str] = None,
+        body: Union[str, bytes, None] = None,
         headers: Optional[Dict] = None,
     ):
         """
diff --git a/tests/functional/event_handler/test_api_gateway.py b/tests/functional/event_handler/test_api_gateway.py
index 4b1d7c1ee32..145d435688a 100644
--- a/tests/functional/event_handler/test_api_gateway.py
+++ b/tests/functional/event_handler/test_api_gateway.py
@@ -1289,3 +1289,10 @@ def handler(event: APIGatewayProxyEventV2, context):
     # THEN
     result = handler(load_event("apiGatewayProxyV2Event.json"), None)
     assert result["statusCode"] == 200
+
+
+def test_response_with_status_code_only():
+    ret = Response(status_code=204)
+    assert ret.status_code == 204
+    assert ret.body is None
+    assert ret.headers == {}