diff --git a/.travis.yml b/.travis.yml
index 6ad4343..3301170 100644
--- a/.travis.yml
+++ b/.travis.yml
@@ -22,6 +22,7 @@ env:
 
 jobs:
   include:
+    # Remove this one on 1.4 release
     - os: linux
       env:
         - MB_PYTHON_VERSION=3.7
@@ -37,6 +38,14 @@ jobs:
         - MB_PYTHON_VERSION=3.9
         - NP_BUILD_DEP="numpy==1.19.1"
         - NP_TEST_DEP="numpy==1.19.1"
+    - os: linux
+      env:
+        - MB_PYTHON_VERSION="3.10"
+        - NP_BUILD_DEP="numpy==1.21.2"
+        - NP_TEST_DEP="numpy==1.21.2"
+        - CYTHON_BUILD_DEP="cython==0.29.24"
+        # Xenial is EOL and the pip there doesn't support python 3.10
+        - DOCKER_TEST_IMAGE="multibuild/focal_arm64v8"
 before_install:
     # See:
     # https://github.com/travis-ci/travis-ci/issues/8920#issuecomment-352661024
@@ -60,7 +69,7 @@ script:
     - source multibuild/travis_steps.sh
     - source extra_functions.sh
     - setup_test_venv
-    - install_run $PLAT
+    - install_run $PLAT;
     - teardown_test_venv
 
 after_success:
diff --git a/azure-pipelines.yml b/azure-pipelines.yml
index 3f35941..e5b25fa 100644
--- a/azure-pipelines.yml
+++ b/azure-pipelines.yml
@@ -92,6 +92,13 @@ jobs:
           MB_ML_VER: "2014"
           NP_BUILD_DEP: "numpy==1.19.3"
           NIGHTLY_BUILD: "true"
+        py_3.10_64:
+          MB_PYTHON_VERSION: "3.10"
+          MB_ML_VER: "2014"
+          NP_BUILD_DEP: "numpy==1.21.2"
+          CYTHON_BUILD_DEP: "cython==0.29.24"
+          DOCKER_TEST_IMAGE: "multibuild/focal_{PLAT}"
+          NIGHTLY_BUILD: "true"
 
 
   - template: azure/posix.yml
diff --git a/azure/posix.yml b/azure/posix.yml
index 72535b0..6da1f3f 100644
--- a/azure/posix.yml
+++ b/azure/posix.yml
@@ -29,6 +29,7 @@ jobs:
         inputs:
           versionSpec: $(MB_PYTHON_VERSION)
         displayName: Set python version
+        condition: not(eq(variables['MB_PYTHON_VERSION'], '3.10'))
 
       - bash: |
           set -e
diff --git a/config.sh b/config.sh
index 3e48b8c..f8d41a3 100644
--- a/config.sh
+++ b/config.sh
@@ -34,5 +34,10 @@ function run_tests {
     # Skip test_rolling_var_numerical_issues: https://github.com/pandas-dev/pandas/issues/37398
     # Skip test_rolling_skew_kurt_large_value_range: https://github.com/pandas-dev/pandas/issues/37398
     # Skip test_pairwise_with_self/test_no_pairwise_with_self: https://github.com/pandas-dev/pandas/issues/39553
-    python -c 'import pandas; pandas.test(extra_args=["-m not clipboard", "--skip-slow", "--skip-network", "--skip-db", "-n=2", "-k not test_rolling_var_numerical_issues and not test_rolling_skew_kurt_large_value_range and not test_float_precision_options and not test_pairwise_with_self and not test_no_pairwise_with_self"])'
+    # Skip reduction tests and window test corr_sanity due to numpy issues: https://github.com/pandas-dev/pandas/issues/41935
+    if [[ "$MB_PYTHON_VERSION" == "3.10" ]]; then
+        python -c 'import pandas; pandas.test(extra_args=["-m not clipboard", "--skip-slow", "--skip-network", "--skip-db", "-n=2", "-k not test_rolling_var_numerical_issues and not test_rolling_skew_kurt_large_value_range and not test_float_precision_options and not test_pairwise_with_self and not test_no_pairwise_with_self and not test_corr_sanity and not TestReductions and not TestIndexReductions"])'
+    else
+        python -c 'import pandas; pandas.test(extra_args=["-m not clipboard", "--skip-slow", "--skip-network", "--skip-db", "-n=2", "-k not test_rolling_var_numerical_issues and not test_rolling_skew_kurt_large_value_range and not test_float_precision_options and not test_pairwise_with_self and not test_no_pairwise_with_self"])'
+    fi
 }